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Quarterly Financial Data (Unaudited) (Details Textual) (USD $)
In Millions, unless otherwise specified
12 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2012
Dec. 31, 2013
ISIS Pharmaceuticals
Sep. 30, 2013
ISIS Pharmaceuticals
Dec. 31, 2012
ISIS Pharmaceuticals
Jun. 30, 2012
ISIS Pharmaceuticals
Mar. 31, 2012
ISIS Pharmaceuticals
Mar. 31, 2013
Hoechst
Dec. 31, 2013
Hoechst
Schedule Of Development Milestone And Collaboration [Line Items]                
Decrease in share of co-promotion profits due to estimated compensation damages             $ 41.5 $ 49.7
Research and development   10.0 75.0 30.0 12.0 29.0    
Tax accounting correction $ 29.0