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Property and Equipment, Net (Tables)
12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Schedule of estimated useful lives for property and equipment We provide for depreciation and amortization primarily using the straight-line method by charges to the consolidated statements of income in amounts that allocate the cost of property and equipment over their estimated useful lives as follows:
Asset Classification Estimated Useful Life
  
Land improvements 
15 to 20 years
Buildings and improvements 
10 to 40 years
Leasehold improvements Shorter of remaining lease term or useful life of improvements
Machinery and equipment 
3 to 8 years
Office furniture and equipment 
3 to 7 years
Computer hardware and software 
3 to 7 years
Schedule of property and equipment
Property and equipment, net, consisted of the following:
(in thousands)December 31, 2021December 31, 2020
  
Land and improvements$22,642 $13,982 
Buildings and improvements329,091 319,384 
Leasehold improvements93,248 82,459 
Machinery and equipment382,753 353,301 
Office furniture and equipment69,090 67,527 
Computer hardware and software276,895 265,664 
Construction in progress62,339 39,764 
1,236,058 1,142,081 
Less accumulated depreciation and amortization648,391 586,914 
Total property and equipment, net$587,667 $555,167 
Summary of depreciation and amortization, capitalized computer software for internal use and unpaid property equipment reflected in accounts payable and accrued expenses
Below are the amounts of depreciation and amortization of property and equipment, capitalized computer software for internal use, unpaid property and equipment reflected in accounts payable and accrued expenses, and rental and reagent rental program instruments transferred from inventory to property and equipment:
For the Years Ended December 31,
(in thousands)202120202019
   
Depreciation and amortization expense$92,376 $86,095 $78,495 
Capitalized computer software developed for internal use$14,753 $18,472 $20,130 
Unpaid property and equipment, reflected in accounts payable and accrued liabilities$19,326 $13,343 $24,688 
Rental and operating-type reagent rental program instruments transferred from inventory to property and equipment (Note 3)$11,628 $9,645 $14,498