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USD ($)

USD ($) / shares

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   &lt;!-- Begin Block Tagged Note 10 - us-gaap:RestructuringAndRelatedActivitiesDisclosureTextBlock--&gt;
   &lt;div style="margin-left: 0%"&gt;
   &lt;div style="margin-top: 12pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;table width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt; font-family: Arial, Helvetica; color: #000000; background: transparent; text-align: left"&gt;
   &lt;tr&gt;
       &lt;td width="5%"&gt;&lt;/td&gt;
       &lt;td width="95%"&gt;&lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="top"&gt;
       &lt;td&gt;
       &lt;b&gt;&lt;font style="font-family: 'Times New Roman', Times"&gt;10.&amp;#160;&amp;#160;&lt;/font&gt;&lt;/b&gt;
   &lt;/td&gt;
       &lt;td&gt;
       &lt;b&gt;&lt;font style="font-family: 'Times New Roman', Times"&gt;RESTRUCTURING&lt;/font&gt;&lt;/b&gt;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;/table&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       In March 2008, the Company&amp;#8217;s collaborative partner Eli
       Lilly and Company (&amp;#8220;Lilly&amp;#8221;) announced the decision to
       discontinue the
       AIR&lt;sup style="font-size: 85%; vertical-align: text-top"&gt;&amp;#174;&lt;/sup&gt;
       Insulin development program and gave notice of termination under
       the collaborative development and license agreement. In March
       2008, in connection with the program termination, the
       Company&amp;#8217;s board of directors approved a plan (the
       &amp;#8220;2008 Restructuring&amp;#8221;) to reduce the Company&amp;#8217;s
       workforce by approximately 150&amp;#160;employees and to cease
       operations at the Company&amp;#8217;s AIR commercial manufacturing
       facility located in Chelsea, Massachusetts. In connection with
       the 2008 Restructuring, the Company recorded charges of
       $6.9&amp;#160;million during the year ended March&amp;#160;31, 2008.
       Activity related to the 2008 Restructuring was as follows:
   &lt;/div&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;table border="0" width="100%" align="center" cellpadding="0" cellspacing="0" style="font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent; text-align: left"&gt;
   &lt;!-- Table Width Row BEGIN --&gt;
   &lt;tr style="font-size: 1pt" valign="bottom"&gt;
       &lt;td width="87%"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=01 type=maindata --&gt;
       &lt;td width="2%"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=gutter --&gt;
       &lt;td width="1%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=lead --&gt;
       &lt;td width="9%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=body --&gt;
       &lt;td width="1%" align="left"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=hang1 --&gt;
   &lt;/tr&gt;
   &lt;!-- Table Width Row END --&gt;
   &lt;!-- TableOutputHead --&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="2" nowrap="nowrap" align="center" valign="bottom"&gt;
       &lt;b&gt;Facility&lt;br /&gt;
       &lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="2" nowrap="nowrap" align="center" valign="bottom" style="border-bottom: 1px solid #000000"&gt;
       &lt;b&gt;Closure&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="2" nowrap="nowrap" align="center" valign="bottom"&gt;
       &lt;b&gt;(In thousands)&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="line-height: 3pt; font-size: 1pt"&gt;
   &lt;td&gt;&amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;!-- TableOutputBody --&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Balance, April&amp;#160;1, 2009
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       4,193
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Payments
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       (811
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       )
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Other adjustments
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       214
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Balance, March&amp;#160;31, 2010
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       3,596
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Payments
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       (896
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       )
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Other adjustments
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       457
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Balance, March&amp;#160;31, 2011
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       3,157
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;/table&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 0%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
   &lt;/div&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       At March&amp;#160;31, 2011 and 2010, the restructuring liability
       related to the 2008 Restructuring consists of $0.7&amp;#160;million
       and $0.6&amp;#160;million classified as current, respectively, and
       $2.5&amp;#160;million and $3.0&amp;#160;million classified as long-term,
       respectively, in the accompanying consolidated balance sheets.
       As of March&amp;#160;31, 2011, the Company had paid in cash, written
       off, recovered and made restructuring charge adjustments
       totaling approximately $0.7&amp;#160;million in facility closure
       costs, $2.9&amp;#160;million in employee separation costs and
       $0.1&amp;#160;million in other contract termination costs in
       connection with the 2008 Restructuring. The $3.2&amp;#160;million
       remaining in the restructuring accrual at March&amp;#160;31, 2011 is
       expected to be paid out through fiscal 2016 and relates
       primarily to estimates of lease costs associated with the exited
       facility and may require adjustment in the future.
   &lt;/div&gt;
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   &lt;/font&gt;
   &lt;/b&gt;
   &lt;/div&gt;
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   &lt;/div&gt;
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   &lt;/font&gt;
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 -Publisher FASB
 -Name Statement of Financial Accounting Standard (FAS)
 -Number 146
 -Paragraph 20

Reference 2: http://www.xbrl.org/2003/role/presentationRef
 -Publisher SEC
 -Name Staff Accounting Bulletin (SAB)
 -Number Topic 5
 -Section P
 -Subsection 3, 4

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