<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><Version>2.2.0.25</Version><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios><ReportLongName>0207 - Disclosure - Property, Plant and Equipment</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelColumn>false</LabelColumn><CurrencyCode>USD</CurrencyCode><FootnoteIndexer /><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios><MCU><KeyName>4/1/2010 - 3/31/2011
USD ($)

USD ($) / shares

</KeyName><CurrencySymbol>$</CurrencySymbol><contextRef><ContextID>Apr-01-2010_Mar-31-2011</ContextID><EntitySchema>http://www.sec.gov/CIK</EntitySchema><EntityValue>0000874663</EntityValue><PeriodDisplayName /><PeriodType>duration</PeriodType><PeriodStartDate>2010-04-01T00:00:00</PeriodStartDate><PeriodEndDate>2011-03-31T00:00:00</PeriodEndDate><Segments /><Scenarios /></contextRef><UPS><UnitProperty><UnitID>USD</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/iso4217</MeasureSchema><MeasureValue>USD</MeasureValue><MeasureNamespace>iso4217</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty><UnitProperty><UnitID>USDEPS</UnitID><UnitType>Divide</UnitType><NumeratorMeasure><MeasureSchema>http://www.xbrl.org/2003/iso4217</MeasureSchema><MeasureValue>USD</MeasureValue><MeasureNamespace>iso4217</MeasureNamespace></NumeratorMeasure><DenominatorMeasure><MeasureSchema>http://www.xbrl.org/2003/instance</MeasureSchema><MeasureValue>shares</MeasureValue><MeasureNamespace>xbrli</MeasureNamespace></DenominatorMeasure><Scale>0</Scale></UnitProperty><UnitProperty><UnitID>Shares</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/instance</MeasureSchema><MeasureValue>shares</MeasureValue><MeasureNamespace>xbrli</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty><UnitProperty><UnitID>Pure</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/instance</MeasureSchema><MeasureValue>pure</MeasureValue><MeasureNamespace>xbrli</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty></UPS><CurrencyCode>USD</CurrencyCode><OriginalCurrencyCode>USD</OriginalCurrencyCode></MCU><CurrencySymbol>$</CurrencySymbol><Labels><Label Id="1" Label="12 Months Ended" /><Label Id="2" Label="Mar. 31, 2011" /></Labels></Column></Columns><Rows><Row><Id>2</Id><IsAbstractGroupTitle>true</IsAbstractGroupTitle><Level>0</Level><ElementName>us-gaap_PropertyPlantAndEquipmentAbstract</ElementName><ElementPrefix>us-gaap</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><ShortDefinition>No definition available.</ShortDefinition><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsSubReportEnd>false</IsSubReportEnd><IsCalendarTitle>false</IsCalendarTitle><IsTuple>false</IsTuple><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole /><FootnoteIndexer /><Cells><Cell><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText /><NonNumericTextHeader /><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios></Cell></Cells><OriginalInstanceReportColumns /><Unit>Other</Unit><ElementDataType>xbrli:stringItemType</ElementDataType><SimpleDataType>string</SimpleDataType><ElementDefenition>No definition available.</ElementDefenition><IsTotalLabel>false</IsTotalLabel><IsEPS>false</IsEPS><Label>Property, Plant and Equipment [Abstract]</Label></Row><Row><Id>3</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><Level>0</Level><ElementName>us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock</ElementName><ElementPrefix>us-gaap</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><ShortDefinition>No definition available.</ShortDefinition><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsSubReportEnd>false</IsSubReportEnd><IsCalendarTitle>false</IsCalendarTitle><IsTuple>false</IsTuple><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole>verboselabel</PreferredLabelRole><FootnoteIndexer /><Cells><Cell><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --&gt;
   &lt;!-- Begin Block Tagged Note 7 - us-gaap:PropertyPlantAndEquipmentDisclosureTextBlock--&gt;
   &lt;div style="margin-left: 0%"&gt;
   &lt;div style="margin-top: 12pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;table width="100%" border="0" cellpadding="0" cellspacing="0" style="font-size: 10pt; font-family: Arial, Helvetica; color: #000000; background: transparent; text-align: left"&gt;
   &lt;tr&gt;
       &lt;td width="3%"&gt;&lt;/td&gt;
       &lt;td width="97%"&gt;&lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="top"&gt;
       &lt;td&gt;
       &lt;b&gt;&lt;font style="font-family: 'Times New Roman', Times"&gt;7.&amp;#160;&amp;#160;&lt;/font&gt;&lt;/b&gt;
   &lt;/td&gt;
       &lt;td&gt;
       &lt;b&gt;&lt;font style="font-family: 'Times New Roman', Times"&gt;PROPERTY,
       PLANT AND EQUIPMENT&lt;/font&gt;&lt;/b&gt;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;/table&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       Property, plant and equipment consists of the following:
   &lt;/div&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;table border="0" width="100%" align="center" cellpadding="0" cellspacing="0" style="font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent; text-align: left"&gt;
   &lt;!-- Table Width Row BEGIN --&gt;
   &lt;tr style="font-size: 1pt" valign="bottom"&gt;
       &lt;td width="79%"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=01 type=maindata --&gt;
       &lt;td width="2%"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=gutter --&gt;
       &lt;td width="1%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=lead --&gt;
       &lt;td width="6%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=body --&gt;
       &lt;td width="1%" align="left"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=02 type=hang1 --&gt;
       &lt;td width="3%"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=03 type=gutter --&gt;
       &lt;td width="1%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=03 type=lead --&gt;
       &lt;td width="6%" align="right"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=03 type=body --&gt;
       &lt;td width="1%" align="left"&gt;&amp;#160;&lt;/td&gt;&lt;!-- colindex=03 type=hang1 --&gt;
   &lt;/tr&gt;
   &lt;!-- Table Width Row END --&gt;
   &lt;!-- TableOutputHead --&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="6" align="center" valign="bottom" style="border-bottom: 1px solid #000000"&gt;
       &lt;b&gt;March&amp;#160;31,&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="2" nowrap="nowrap" align="center" valign="bottom" style="border-bottom: 1px solid #000000"&gt;
       &lt;b&gt;2011&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="2" nowrap="nowrap" align="center" valign="bottom" style="border-bottom: 1px solid #000000"&gt;
       &lt;b&gt;2010&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="font-size: 8pt" valign="bottom" align="center"&gt;
   &lt;td nowrap="nowrap" align="center" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td colspan="6" align="center" valign="bottom"&gt;
       &lt;b&gt;(In thousands)&lt;/b&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr style="line-height: 3pt; font-size: 1pt"&gt;
   &lt;td&gt;&amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;!-- TableOutputBody --&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Land
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       301
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       301
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Building and improvements
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       36,792
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       36,759
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Furniture, fixture and equipment
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       62,660
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       62,501
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Leasehold improvements
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       44,779
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       42,660
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Construction in progress
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       42,194
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       43,695
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 20pt"&gt;
       Subtotal
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       186,726
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       185,916
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="background: #cceeff"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 10pt"&gt;
       Less: accumulated depreciation
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       (91,706
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       )
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       (89,011
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       )
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 1px solid #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom"&gt;
   &lt;td align="left" valign="bottom"&gt;
   &lt;div style="text-indent: -10pt; margin-left: 20pt"&gt;
       Total property, plant and equipment, net
   &lt;/div&gt;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       95,020
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
       $
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="right" valign="bottom"&gt;
       96,905
   &lt;/td&gt;
   &lt;td nowrap="nowrap" align="left" valign="bottom"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;tr valign="bottom" style="font-size: 1pt"&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td style="border-top: 3px double #000000"&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;td&gt;
   &amp;#160;
   &lt;/td&gt;
   &lt;/tr&gt;
   &lt;/table&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 0%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
   &lt;/div&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       Depreciation expense was $8.7&amp;#160;million, $25.0&amp;#160;million
       and $10.3&amp;#160;million for the years ended March&amp;#160;31, 2011,
       2010 and 2009, respectively. The Company has $0.5&amp;#160;million
       of fully depreciated equipment acquired under a capital lease at
       March&amp;#160;31, 2011 and 2010.
   &lt;/div&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       During the year ended March&amp;#160;31, 2011, the Company wrote off
       furniture, fixtures and equipment that had a carrying value of
       $0.1&amp;#160;million at the time of disposition and received
       proceeds from the sales of furniture, fixtures and equipment of
       $0.4&amp;#160;million. During the year ended March&amp;#160;31, 2010,
       the Company wrote off or sold furniture, fixtures and equipment
       that had a carrying value of $1.3&amp;#160;million at the time of
       disposition and received proceeds from the sales of furniture,
       fixtures and equipment of $0.2&amp;#160;million. During the year
       ended March&amp;#160;31, 2010, in connection with the Company&amp;#8217;s
       relocation of its corporate headquarters from Cambridge,
       Massachusetts to Waltham, Massachusetts in the fourth quarter of
       the year ended March&amp;#160;31, 2010, the Company accelerated the
       depreciation on laboratory related leasehold improvements
       located at the Company&amp;#8217;s Cambridge facility, which no
       longer had any benefit or future use to the Company. The amount
       of accelerated depreciation recorded was $14.1&amp;#160;million.
   &lt;/div&gt;
   &lt;!-- XBRL Pagebreak Begin --&gt;
   &lt;/div&gt;
   &lt;!-- END PAGE WIDTH --&gt;
   &lt;!-- PAGEBREAK --&gt;
   &lt;div style="margin-left: 0%"&gt;
   &lt;!-- BEGIN PAGE WIDTH --&gt;
   &lt;div align="center" style="margin-left: 0%; margin-right: 0%; font-size: 10pt; font-family: Arial, Helvetica; color: #000000; background: transparent"&gt;
   &lt;b&gt;
   &lt;font style="font-family: 'Times New Roman', Times"&gt;
   &lt;/font&gt;
   &lt;/b&gt;
   &lt;/div&gt;
   &lt;div style="margin-top: 0pt; font-size: 1pt"&gt;
   &lt;/div&gt;
   &lt;div align="center" style="margin-left: 0%; margin-right: 0%; font-size: 10pt; font-family: Arial, Helvetica; color: #000000; background: transparent"&gt;
   &lt;b&gt;
   &lt;font style="font-family: 'Times New Roman', Times"&gt;
   &lt;/font&gt;
   &lt;/b&gt;
   &lt;/div&gt;
   &lt;!-- XBRL Pagebreak End --&gt;
   &lt;div style="margin-top: 6pt; font-size: 1pt"&gt;&amp;#160;
   &lt;/div&gt;
   &lt;div align="left" style="margin-left: 0%; margin-right: 0%; text-indent: 4%; font-size: 10pt; font-family: 'Times New Roman', Times; color: #000000; background: transparent"&gt;
       Amounts included as construction in progress in the consolidated
       balance sheets primarily include costs incurred for the
       expansion of the Company&amp;#8217;s manufacturing facilities in
       Ohio. The Company continues to evaluate its manufacturing
       capacity based on expectations of demand for its products and
       will continue to record such amounts within construction in
       progress until such time as the underlying assets are placed
       into service, or the Company determines it has sufficient
       existing capacity and the assets are no longer required, at
       which time the Company would recognize an impairment charge. The
       Company continues to periodically evaluate whether facts and
       circumstances indicate that the carrying value of these
       long-lived assets to be held and used may not be recoverable.
   &lt;/div&gt;
   &lt;/div&gt;
</NonNumbericText><NonNumericTextHeader>&lt;!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --&gt;
   &lt;!-- Begin Block Tagged Note</NonNumericTextHeader><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios></Cell></Cells><OriginalInstanceReportColumns /><Unit>Other</Unit><ElementDataType>us-types:textBlockItemType</ElementDataType><SimpleDataType>string</SimpleDataType><ElementDefenition>Disclosure of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. Examples include land, building and production equipment. This disclosure may include property plant and equipment accounting policies and methodology, a schedule of property, plant and equipment gross, additions, deletions, transfers and other changes, depreciation, depletion and amortization expense, net, accumulated depreciation, depletion and amortization expense and useful lives, income statement disclosures, assets held for sale and public utility disclosures. This element may be used as a single block of text to include the entire PPE disclosure, including data and tables.</ElementDefenition><ElementReferences>Reference 1: http://www.xbrl.org/2003/role/presentationRef
 -Publisher AICPA
 -Name Accounting Principles Board Opinion (APB)
 -Number 12
 -Paragraph 5

</ElementReferences><IsTotalLabel>false</IsTotalLabel><IsEPS>false</IsEPS><Label>PROPERTY, PLANT AND EQUIPMENT</Label></Row></Rows><Footnotes /><NumberOfCols>1</NumberOfCols><NumberOfRows>2</NumberOfRows><ReportName>Property, Plant and Equipment</ReportName><MonetaryRoundingLevel>UnKnown</MonetaryRoundingLevel><SharesRoundingLevel>UnKnown</SharesRoundingLevel><PerShareRoundingLevel>UnKnown</PerShareRoundingLevel><ExchangeRateRoundingLevel>UnKnown</ExchangeRateRoundingLevel><HasCustomUnits>false</HasCustomUnits><SharesShouldBeRounded>true</SharesShouldBeRounded></InstanceReport>
