144 0001276128 XXXXXXXX LIVE 0000874015 IONIS PHARMACEUTICALS INC 000-19125 2855 GAZELLE COURT CARLSBAD CA 92010 7609319200 LOSCALZO JOSEPH Director Common Stock Stifel Nicolaus & Company Inc

501 N Broadway St. Louis MO 63102

54321 4345680.00 165262556 05/04/2026 Nasdaq Common Stock 07/01/2021 Option Exercise Issuer N 12000 05/04/2026 Cash Common Stock 07/03/2023 Option Exercise Issuer N 10321 05/04/2026 Cash Common Stock 07/02/2018 Option Exercise Issuer N 16000 05/04/2026 Cash Common Stock 07/01/2020 Option Exercise Issuer N 12000 05/04/2026 Cash Common Stock 07/01/2019 Option Exercise Issuer N 16000 05/04/2026 Cash N Joseph Loscalzo

2855 Gazelle Ct Carlsbad CA 92010

Common Stock 03/03/2026 832 66833.00 Joseph Loscalzo

2855 Gazelle Ct Carlsbad CA 92010

Common Stock 03/04/2026 200 16000.00 05/04/2026 11/18/2025 /s/ James Weimer, as a duly authorized representative of STIFEL, as attorney-in-fact for Joseph Loscalzo