144 0001773314 XXXXXXXX LIVE 0000874015 IONIS PHARMACEUTICALS INC 000-19125 2855 GAZELLE COURT CARLSBAD CA 92010 7609319200 Diaz Allene M. Director Common Stock Stifel Nicolaus & Company Inc

501 N Broadway St. Louis MO 63102

68800 5469600.00 161970000 03/03/2026 Nasdaq Common Stock 07/01/2021 Option Exercise Issuer N 50432 03/03/2026 Cash Common Stock 01/15/2021 Restricted Stock Units Issuer N 18368 01/15/2021 Equity Compensation Y 03/31/2026 11/25/2025 /s/ James Weimer, as a duly authorized representative of STIFEL, as attorney-in-fact for Allene Diaz