144/A 0001972481-26-000114 0001838539 XXXXXXXX LIVE 0000874015 IONIS PHARMACEUTICALS INC 000-19125 2855 GAZELLE COURT CARLSBAD CA 92010 7609319200 Schneider Eugene Officer Common Stock Stifel Nicolaus & Company Inc

501 N Broadway St. Louis MO 63102

5812 412486.00 165190000 03/19/2026 Nasdaq Common Stock 01/15/2026 Performance Stock Units Issuer N 5812 01/15/2026 Equity Compensation N Eugene Schneider

2855 Gazelle Ct Carlsbad CA 92010

Common Stock 01/30/2026 6179 512906.00 Eugene Schneider

2855 Gazelle Ct Carlsbad CA 92010

Common Stock 01/16/2026 9302 703138.00 03/24/2026 11/19/2025 /s/ James Weimer, as a duly authorized representative of STIFEL, as attorney-in-fact for Eugene Schneider