<SEC-DOCUMENT>0001193125-23-039063-index.html : 20230214
<SEC-HEADER>0001193125-23-039063.hdr.sgml : 20230214
<ACCEPTANCE-DATETIME>20230214160712
ACCESSION NUMBER:		0001193125-23-039063
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230214
DATE AS OF CHANGE:		20230214
GROUP MEMBERS:		BIOTECH INVEST N.V.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-41771
		FILM NUMBER:		23629067

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BB BIOTECH AG
		CENTRAL INDEX KEY:			0000924223
		STANDARD INDUSTRIAL CLASSIFICATION:	UNKNOWN SIC - 0000 [0000]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		SCHWERTSTRASSE 6
		CITY:			SCHAFFHAUSEN
		STATE:			V8
		ZIP:			8200
		BUSINESS PHONE:		411724 59 59

	MAIL ADDRESS:	
		STREET 1:		SCHWERTSTRASSE 6
		CITY:			SCHAFFHAUSEN
		STATE:			V8
		ZIP:			8200
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>d394406dsc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
Document 1 - file: d394406dsc13ga.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.B
<SEQUENCE>2
<FILENAME>d394406dex99b.htm
<DESCRIPTION>EX-99.B
<TEXT>
Document 2 - file: d394406dex99b.htm

</DOCUMENT>
</SEC-DOCUMENT>