<SEC-DOCUMENT>0001193125-20-236406-index.html : 20200831
<SEC-HEADER>0001193125-20-236406.hdr.sgml : 20200831
<ACCEPTANCE-DATETIME>20200831172829
ACCESSION NUMBER:		0001193125-20-236406
CONFORMED SUBMISSION TYPE:	SC TO-C
PUBLIC DOCUMENT COUNT:		5
FILED AS OF DATE:		20200831
DATE AS OF CHANGE:		20200831
GROUP MEMBERS:		AVALANCHE MERGER SUB, INC.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			AKCEA THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001662524
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				472608175
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-C
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90051
		FILM NUMBER:		201152652

	BUSINESS ADDRESS:	
		STREET 1:		22 BOSTON WHARF RD
		STREET 2:		9TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		617-207-0202

	MAIL ADDRESS:	
		STREET 1:		22 BOSTON WHARF RD
		STREET 2:		9TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC TO-C

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC TO-C
<SEQUENCE>1
<FILENAME>d66298dsctoc.htm
<DESCRIPTION>SC TO-C
<TEXT>
Document 1 - file: d66298dsctoc.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>2
<FILENAME>d66298dex992.htm
<DESCRIPTION>EX-99.2
<TEXT>
Document 2 - file: d66298dex992.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>3
<FILENAME>d66298dex993.htm
<DESCRIPTION>EX-99.3
<TEXT>
Document 3 - file: d66298dex993.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.4
<SEQUENCE>4
<FILENAME>d66298dex994.htm
<DESCRIPTION>EX-99.4
<TEXT>
Document 4 - file: d66298dex994.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.5
<SEQUENCE>5
<FILENAME>d66298dex995.htm
<DESCRIPTION>EX-99.5
<TEXT>
Document 5 - file: d66298dex995.htm

</DOCUMENT>
</SEC-DOCUMENT>