0001140361-21-036328.txt : 20211103 0001140361-21-036328.hdr.sgml : 20211103 20211103111524 ACCESSION NUMBER: 0001140361-21-036328 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 15 CONFORMED PERIOD OF REPORT: 20211103 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20211103 DATE AS OF CHANGE: 20211103 FILER: COMPANY DATA: COMPANY CONFORMED NAME: IONIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 211374247 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 FORMER COMPANY: FORMER CONFORMED NAME: ISIS PHARMACEUTICALS INC DATE OF NAME CHANGE: 19930328 8-K 1 brhc10030336_8k.htm 8-K
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
 
FORM 8-K
 
CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d) OF THE
SECURITIES EXCHANGE ACT OF 1934
 
Date of report (Date of earliest event reported):  November 3, 2021
 
IONIS PHARMACEUTICALS, INC.
(Exact Name of Registrant as Specified in Charter)
 
Delaware
(State or Other Jurisdiction of Incorporation)
 
000-19125
  
33-0336973
(Commission File No.)
  
(IRS Employer Identification No.)

2855 Gazelle Court
Carlsbad, CA 92010
(Address of Principal Executive Offices and Zip Code)
 
Registrant’s telephone number, including area code: (760) 931-9200

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class
  
Trading symbol
  
Name of each exchange on which registered
Common Stock, $.001 Par Value
  
“IONS”
  
The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (Section 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (Section 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐
 
Item 2.02.
Results of Operations and Financial Condition.
 
On November 3, 2021, Ionis Pharmaceuticals, Inc. (the “Company”) issued a press release announcing the Company’s financial results for the quarter ended September 30, 2021.  In addition to disclosing results that are determined in accordance with Generally Accepted Accounting Principles (“GAAP”), the Company also discloses pro forma or non-GAAP results of operations, which are adjusted from GAAP to exclude non-cash compensation expense related to equity awards, expenses related to the Company’s merger transaction with Akcea Therapeutics, Inc. (“Akcea”), and expenses related to the Company’s restructured commercial operations and the related tax effects. The Company is presenting pro forma information excluding non-cash compensation expense related to equity awards, expenses related to the Akcea merger, and expenses related to the restructured commercial operations and related tax effects because the Company believes it is useful for investors in assessing the Company’s operating results compared to the prior year.  A copy of the release is furnished with this report as an exhibit pursuant to “Item 2.02. Results of Operations and Financial Condition” of Form 8-K in accordance with SEC Release Nos. 33-8216 and 34-47583.
 
The information in this Current Report on Form 8-K and the Exhibit attached hereto shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, regardless of any general incorporation language in such filing.
 
Item 9.01.
Financial Statements and Exhibits.
 
(d) Exhibits.
 
Exhibit No.
Description
Press Release dated November 3, 2021.
   
104
Cover Page Interactive Data File (embedded within the Inline XBRL document).

SIGNATURE
 
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 
 
Ionis Pharmaceuticals, Inc.
     
Dated: November 3, 2021
 By:
/s/ Patrick R. O’Neil
   
Patrick R. O’Neil
   
Executive Vice President, Chief Legal Officer and General Counsel


EX-99.1 2 brhc10030336_ex99-1.htm EXHIBIT 99.1
Exhibit 99.1


Ionis reports third quarter 2021 financial results and recent business achievements

Olezarsen (IONIS-APOCIII-LRx) Phase 3 CORE study in patients with sHTG initiated
 
Donidalorsen (IONIS-PKK-LRx) Phase 2 data to be presented at ACAAI Annual Meeting; Phase 3 initiation on track for year-end
 
Tofersen Phase 3 VALOR study missed primary endpoint; signs of reduced disease progression observed across multiple secondary and exploratory endpoints
 
Webcast today, November 3, 2021, at 11:30 a.m. Eastern Time
 
CARLSBAD, Calif., November 3, 2021 – Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today reported financial results for the three and nine months ended September 30, 2021 and recent business achievements.
 
“Among recent business highlights, we further expanded our broad late-stage pipeline to seven Phase 3 programs now that the olezarsen Phase 3 CORE study in patients with severe hypertriglyceridemia is underway. We were encouraged that while tofersen did not achieve the primary endpoint in the Phase 3 VALOR study, trends favoring tofersen were seen across multiple secondary and exploratory measures of disease progression in patients with SOD1-ALS. We also expanded our LICA platform capabilities by licensing technology from Bicycle Therapeutics,” said Brett P. Monia, Ph.D., chief executive officer of Ionis. “We are looking forward to multiple near-term catalysts, beginning with the presentation of donidalorsen Phase 2 data in patients with hereditary angioedema at the ACAAI Annual Meeting this weekend. We anticipate initiating the donidalorsen Phase 3 study before year-end. We also expect multiple catalysts in 2022, including results from the eplontersen Phase 3 study in patients with TTR polyneuropathy mid-year 2022. Furthermore, at our virtual investor day on December 9th, we look forward to outlining commercial preparations for our lead programs ahead of our first potential launch with eplontersen in patients with TTR polyneuropathy in 2023. Based on our anticipated near- and mid-term catalysts, we remain on track to have 12 or more products on the market in 2026.”
 
Third Quarter 2021 Financial Results
 

 •
Third quarter results reflect Ionis’ focus on its strategic objectives

o
$133 million in total revenues

o
$185 million of operating expenses on a non-GAAP basis(1) and $219 million on a GAAP basis

o
Net loss of $48 million on a non-GAAP basis(1) and $82 million on a GAAP basis


•
Well capitalized with cash and investments of $2 billion as of September 30, 2021

“Since our last quarterly update, we further advanced our strategic objectives through investments in our expanding Phase 3 pipeline and technology. We also advanced our commercial readiness initiatives in anticipation of multiple product launches potentially beginning as early as 2023,” said Elizabeth L. Hougen, chief financial officer of Ionis. “We remain on track to achieve our 2021 financial guidance driven by increased R&D revenue in the fourth quarter as several of our partner programs advance. We also project increased expenses in the fourth quarter as we continue to invest for growth. Importantly, with $2 billion in cash, we remain well-capitalized with the resources we need to achieve our strategic objectives.”


 (1)
All non-GAAP amounts referred to in this press release exclude non-cash compensation expense related to equity awards and expenses related to the Akcea Merger and restructured commercial operations and the related tax effects. Please refer to the section below titled “Financial Impacts of Akcea Merger and Restructured Commercial Operations” for a summary of the costs specific to these transactions. Additionally, please refer to the detailed reconciliation of non-GAAP and GAAP measures, which is provided later in this press release.
 
1
Third Quarter 2021 Marketed Products Highlights
 

 •
SPINRAZA®: the global market leader for the treatment of spinal muscular atrophy (SMA) patients of all ages

o
$444 million in worldwide sales in the third quarter

o
More than 11,000 patients worldwide on therapy at the end of the third quarter across commercial, expanded access and clinical trial settings

o
Biogen plans to initiate the Phase 3b ASCEND study evaluating the potential benefit of an investigational higher dose of nusinersen in children, teens and adults with later-onset SMA previously treated with Evrysdi® (risdiplam)


•
TEGSEDI® and WAYLIVRA®: important medicines approved for the treatment of patients with severe rare diseases

o
TEGSEDI achieved innovative drug pricing in Brazil reflecting the significant unmet medical need and prevalence of TTR polyneuropathy in Brazil

o
WAYLIVRA was approved in Brazil as the first and only treatment for patients with familial chylomicronemia syndrome
 
Third Quarter 2021 and Recent Events
 

 •
Advancing Ionis’ leading cardiovascular and metabolic disease pipeline

o
Initiated the Phase 3 CORE study of olezarsen (IONIS-APOCIII-LRx) in patients with severe hypertriglyceridemia (sHTG)

o
Reached 50 percent enrollment in the Phase 3 Lp(a) HORIZON outcome study of pelacarsen for patients with established cardiovascular disease and elevated Lp(a), resulting in a $25 million payment from Novartis

o
Achieved full enrollment in the Bayer Phase 2b RE-THINc ESRD study of fesomersen (IONIS-FXI-LRx), with data expected in the first half of 2022

o
Achieved proof-of-mechanism, a strong indication of proof-of-concept and good safety and tolerability in a Phase 2 study and a preliminary assessment from an open-label extension study of cimdelirsen (IONIS-GHR-LRx) in acromegaly patients uncontrolled on standard of care therapy, supporting continued development. Data from the ongoing open-label extension study and monotherapy study are expected in 2022. The results from the Phase 2 study of cimdelirsen are posted to Ionis’ website and may be accessed here


•
Addressing substantial unmet medical need with Ionis’ broad neurological disease pipeline

o
The Biogen Phase 3 VALOR study of tofersen in patients with SOD1-ALS did not meet the primary endpoint of change from baseline to week 28 in the ALS Functional Rating Scale-Revised (ALSFRS-R); however, signs of reduced disease progression across multiple secondary and exploratory endpoints were observed

o
Achieved full enrollment in the Phase 3 NEURO-TTRansform study of eplontersen in patients with TTR polyneuropathy, with data expected in mid-2022

o
Reported data from the Biogen Phase 1/2 study of IONIS-MAPTRx in patients with Alzheimer’s disease, demonstrating durable, time and dose-dependent reductions in CSF tau protein; IONIS-MAPTRx was generally well tolerated
 

 •
Investing in expanding the reach of Ionis’ technology

o
Entered a license agreement with Bicycle Therapeutics for exclusive rights to Bicycle’s peptide technology targeting transferrin receptor 1 to expand the capabilities of Ionis’ LICA technology

o
Entered a license agreement with Flamingo Therapeutics for the development and commercialization of programs from Ionis’ oncology pipeline
 
2
2021 Pipeline Milestones(2)

Anticipated Key 2021 Data Readouts
 
Program
  
Phase
  
Anticipated Indication
H1
H2
 
Donidalorsen
  
2
  
Hereditary angioedema (top-line data)
 
 
IONIS-AGT-LRx
  
2
  
Hypertension
 
 
Tominersen
  
3
  
Huntington’s disease
 
 
IONIS-ENAC-2.5Rx
  
2
  
Cystic fibrosis
 
 
IONIS-MAPTRx
  
1/2
  
Alzheimer’s disease
  
 
Tofersen
  
3 (VALOR)
  
SOD1-ALS
  
 
Cimdelirsen
  
2 + OLE
  
Acromegaly
  
 
Donidalorsen
  
2
  
Hereditary angioedema (full data)
  
•
 
ION449 (PCSK9)
  
1 (MAD)
  
Dyslipidemia
  
•
 
Vupanorsen
  
2b
  
sHTG/CVD risk reduction
  
•

Anticipated Key 2021 Study Initiations
 
Program
  
Phase
  
Anticipated Indication
H1
H2
 
SPINRAZA
  
4 (RESPOND)
  
SMA, suboptimal gene therapy response
 
 
Tofersen
  
3 (ATLAS)
  
Presymptomatic SOD1-ALS
 
 
ION363
  
3
  
FUS-ALS
 
 
IONIS-AGT-LRx
  
2 & 2b
  
Heart failure & resistant hypertension
 
 
ION373
  
2/3
  
Alexander disease
 
 
ION224
  
2b
  
NASH
 
 
Olezarsen
  
3 (CORE)
  
Severe hypertriglyceridemia (sHTG)
  
 
Donidalorsen
  
3
  
Hereditary angioedema
  
•
 
SPINRAZA
  
3b (ASCEND)
  
SMA, previous risdiplam treatment
  
•
 
ION582
  
2
  
Angelman syndrome
  
•
= achieved      • = planned

(2) Timing of partnered program catalysts based on partners’ most recent publicly available disclosures

Third Quarter 2021 Financial Results

Revenue
 
Ionis' revenue was comprised of the following (amounts in millions):
 
   
Three months ended,
September 30,
    
Nine months ended
September 30,
  
   
2021
    
2020
    
2021
    
2020
  
Revenue:
                  
Commercial revenue:
                        
SPINRAZA royalties
  
$
67
    
$
74
    
$
199
    
$
212
  
TEGSEDI and WAYLIVRA revenue, net
    
15
      
19
      
47
      
51
  
Licensing and royalty revenue
    
3
      
2
      
9
      
6
  
Total commercial revenue
    
85
      
95
      
255
      
269
  
R&D revenue:
                                
Amortization from upfront payments
    
17
      
19
      
57
      
68
  
Milestone payments
    
28
      
44
      
48
      
73
  
License fees
    
-
      
-
      
-
      
15
  
Other services
    
3
      
2
      
10
      
14
  
Total R&D revenue
    
48
      
65
      
115
      
170
  
Total revenue
  
$
133
    
$
160
    
$
370
    
$
439
  

3
In the third quarter of 2021, the Company continued to advance its late-stage pipeline, including reaching 50 percent enrollment in the Phase 3 Lp(a) HORIZON study of pelacarsen for which it earned a $25 million milestone payment from Novartis. As its partnered programs advance, the Company expects R&D revenue to increase in the fourth quarter of 2021 compared with the third quarter of 2021.
 
In the second quarter of 2021, the Company successfully completed the transition of its TEGSEDI operations in North America to Sobi. As a result, the Company’s commercial revenue from product sales shifted to distribution fees based on net sales generated by Sobi. In the third quarter of 2021, the Company earned a $4 million milestone payment from PTC Therapeutics when WAYLIVRA was approved in Brazil.

Financial Impacts of Akcea Merger and Restructured Commercial Operations
 
In October 2020 Ionis completed a merger transaction with Akcea such that following the completion of the merger Akcea became a wholly owned subsidiary of Ionis.  Additionally, in December 2020 and April 2021, Ionis restructured its European operations and its North American TEGSEDI operations, respectively, as a result of entering into distribution agreements with Sobi.  For the three and nine months ended September 30, 2021, the Company incurred $3 million and $24 million of costs in conjunction with the Akcea merger and restructuring of the Company’s commercial operations, respectively. The Company excluded these costs from its non-GAAP amounts for those periods. Please refer to the detailed reconciliation of non-GAAP and GAAP measures that is provided later in this press release.

Operating Expenses
 
Ionis’ operating expenses for the three and nine months ended September 30, 2021 increased compared with the same periods last year driven by an increase in R&D expenses, partially offset by a decrease in SG&A expenses. Higher R&D expenses were primarily driven by the Company’s investments in advancing its late-stage wholly owned pipeline, including advancing the Phase 3 program for eplontersen and start-up costs associated with the Phase 3 study for a second indication for olezarsen. Additionally, the Company recognized $35 million in R&D expense in the third quarter of 2021 for licensing Bicycle’s technology. Lower SG&A expenses primarily reflect operating efficiencies achieved from integrating Akcea and restructuring the Company’s commercial operations. The Company projects its operating expenses to increase in the fourth quarter as it continues to invest for growth.

Net Loss Attributable to Ionis Common Stockholders

Net loss attributable to Ionis’ common stockholders for the three and nine months ended September 30, 2021 increased compared with the same periods in the prior year for the reasons discussed above.

Balance Sheet

As of September 30, 2021 Ionis had cash, cash equivalents and short-term investments of $2.0 billion, compared with $1.9 billion as of December 31, 2020. The Company intends to utilize $62 million of its cash to pay the remaining principal balance of its 1 percent convertible notes at maturity in November 2021.

The Company revised its 2020 amounts to reflect the simplified convertible instruments guidance the Company adopted retrospectively on January 1, 2021.

4
Webcast

Ionis will conduct a webcast today at 11:30 a.m. Eastern time to discuss this announcement and related activities. Interested parties may access the webcast here. A webcast replay will be available for a limited time at the same address.

About Ionis Pharmaceuticals, Inc.
 
For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing the standards of care with its novel antisense technology. Ionis currently has three marketed medicines and a premier late-stage pipeline highlighted by industry leading neurological and cardiometabolic franchises. Our scientific innovation began and continues with the knowledge that sick people depend on us, which fuels our vision of becoming one of the most successful biotechnology companies.

To learn more about Ionis visit www.ionispharma.com or follow us on Twitter @ionispharma.

Ionis’ Forward-looking Statement
 
This press release includes forward-looking statements regarding Ionis’ business, financial guidance and the therapeutic and commercial potential of SPINRAZA (nusinersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen) and Ionis' technologies and products in development. Any statement describing Ionis’ goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to certain risks and uncertainties, including those related to the impact COVID-19 could have on our business, and including those inherent in the process of discovering, developing and commercializing medicines that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such medicines. Ionis’ forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Ionis’ forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Ionis. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Ionis' programs are described in additional detail in Ionis' annual report on Form 10-K for the year ended December 31, 2020, and the most recent Form 10-Q quarterly filing, which are on file with the SEC. Copies of these and other documents are available from the Company.

In this press release, unless the context requires otherwise, “Ionis,” “Company,” “we,” “our” and “us” all refer to Ionis Pharmaceuticals and its subsidiaries.

Ionis Pharmaceuticals® is a trademark of Ionis Pharmaceuticals, Inc. Akcea Therapeutics® is a registered trademark of Akcea Therapeutics, Inc. TEGSEDI® is a registered trademark of Akcea Therapeutics, Inc. WAYLIVRA® is a registered trademark of Akcea Therapeutics, Inc. SPINRAZA® is a registered trademark of Biogen.

Ionis Pharmaceuticals Investor Contact:
760-603-2331

Ionis Pharmaceuticals Media Contact:
760-603-2681

5
IONIS PHARMACEUTICALS, INC.
SELECTED FINANCIAL INFORMATION
Condensed Consolidated Statements of Operations
(In Millions, Except Per Share Data)

   
Three months ended, ended,
September 30,
    
Nine months ended,
September 30,
  
   
2021
    
2020
    
2021
    
2020
  
   
(as revised*)
          
(as revised*)
  
   
(unaudited)
  
Revenue:
                        
Commercial revenue:
                        
SPINRAZA royalties
  
$
67
    
$
74
    
$
199
    
$
212
  
TEGSEDI and WAYLIVRA revenue, net
    
15
      
19
      
47
      
51
  
Licensing and royalty revenue
    
3
      
2
      
9
      
6
  
Total commercial revenue
    
85
      
95
      
255
      
269
  
Research and development revenue under collaborative agreements
    
48
      
65
      
115
      
170
  
Total revenue
    
133
      
160
      
370
      
439
  
Expenses:
                                
Cost of sales
    
3
      
3
      
9
      
9
  
Research, development and patent
    
185
      
125
      
464
      
364
  
Selling, general and administrative
    
31
      
69
      
148
      
215
  
Total operating expenses
    
219
      
197
      
621
      
588
  
Loss from operations
    
(86
)
    
(37
)
    
(251
)
    
(149
)
                                 
Other income (expense):
                                
Loss on early retirement of debt
    
-
      
-
      
(9
)
    
-
  
Other income, net
    
2
      
5
      
6
      
29
  
Loss before income tax benefit (expense)
    
(84
)
    
(32
)
    
(254
)
    
(120
)
                                 
Income tax benefit (expense)
    
2
      
(5
)
    
1
      
(4
)
                                 
Net loss
  
$ 
(82
)
  
$ 
(37
)
  
$ 
(253
)
  
$ 
(124
)
Net loss attributable to noncontrolling interest in Akcea Therapeutics, Inc.
  
$
-
    
$
13
    
$
-
    
$
34
  
Net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders
  
$ 
(82
)
  
$ 
(24
)
  
$ 
(253
)
  
$ 
(90
)
                                 
Basic and diluted net loss per share
  
$ 
(0.58
)
  
$ 
(0.18
)
  
$ 
(1.80
)
  
$ 
(0.64
)
Shares used in computing basic and diluted net loss per share
    
141
      
140
      
141
      
139
  

*The Company revised its 2020 amounts to reflect the simplified convertible instruments guidance the Company adopted retrospectively on January 1, 2021.
 
6
IONIS PHARMACEUTICALS, INC.
Reconciliation of GAAP to Non-GAAP Basis:
Condensed Consolidated Operating Expenses, Income (Loss) From Operations, and Net Income (Loss)
(In Millions)

   
Three months ended,
September 30,
    
Nine months ended,
September 30,
  
   
2021
    
2020
    
2021
    
2020
  
         
(as revised*)
          
(as revised*)
  
   
(unaudited)
  
As reported research, development and patent expenses according to GAAP
  
$
185
    
$
125
    
$
464
    
$
364
  
Excluding compensation expense related to equity awards
    
(23
)
    
(25
)
    
(72
)
    
(77
)
Excluding Akcea merger and restructured commercial operation costs**
    
(2
)
    
-
      
(8
)
    
-
  
                                 
Non-GAAP research, development and patent expenses
  
$
160
    
$
100
    
$
384
    
$
287
  
As reported selling, general and administrative expenses according to GAAP
  
$
31
    
$
69
    
$
148
    
$
215
  
Excluding compensation expense related to equity awards
    
(7
)
    
(20
)
    
(26
)
    
(57
)
Excluding Akcea merger and restructured commercial operation costs**
    
(1
)
    
-
      
(16
)
    
-
  
                                 
Non-GAAP selling, general and administrative expenses
  
$
23
    
$
49
    
$
106
    
$
158
  
As reported operating expenses according to GAAP
  
$
219
    
$
197
    
$
621
    
$
588
  
Excluding compensation expense related to equity awards
    
(31
)
    
(46
)
    
(98
)
    
(135
)
Excluding Akcea merger and restructured commercial operation costs**
    
(3
)
    
-
      
(24
)
    
-
  
                                 
Non-GAAP operating expenses
  
$
185
    
$
151
    
$
499
    
$
453
  
                                 
As reported loss from operations according to GAAP
  
$ 
(86
)
  
$ 
(37
)
  
$ 
(251
)
  
$ 
(149
)
Excluding compensation expense related to equity awards
    
(31
)
    
(46
)
    
(98
)
    
(135
)
Excluding Akcea merger and restructured commercial operation costs**
    
(3
)
    
-
      
(24
)
    
-
  
Non-GAAP income (loss) from operations
  
$ 
(52
)
  
$
9
    
$
(129
)
  
$ 
(14
)
As reported net loss attributable to Ionis Pharmaceuticals, Inc. common stockholders according to GAAP
  
$ 
(82
)
  
$ 
(24
)
  
$ 
(253
)
  
$ 
(90
)
Excluding compensation expense related to equity awards attributable to Ionis Pharmaceuticals, Inc. common stockholders
    
(31
)
    
(42
)
    
(98
)
    
(126
)
Excluding Akcea merger and restructured commercial operation costs**
    
(3
)
    
-
      
(24
)
    
-
  
Income tax effect related to compensation expense related to equity awards attributable to Ionis Pharmaceuticals, Inc. common stockholders
    
-
      
6
      
-
      
18
  
Non-GAAP net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders according to GAAP
  
$ 
(48
)
  
$
12
    
$ 
(131
)
  
$
18
  

*The Company revised its 2020 amounts to reflect the simplified convertible instruments guidance the Company adopted retrospectively on January 1, 2021.
 
** In October 2020, Ionis completed a merger transaction with Akcea such that following the completion of the merger Akcea became a wholly owned subsidiary of Ionis.
 
7
Reconciliation of GAAP to Non-GAAP Basis
 
As illustrated in the Selected Financial Information in this press release, non-GAAP operating expenses, non-GAAP income (loss) from operations, and non-GAAP net income (loss) attributable to Ionis Pharmaceuticals, Inc. common stockholders were adjusted from GAAP to exclude compensation expense related to equity awards and costs related to the Akcea merger and restructured commercial operations and the related tax effects. Compensation expense related to equity awards are non-cash. Costs related to the Akcea merger and restructured commercial operations include: severance costs, retention costs and other costs related to commercial operations. Ionis has regularly reported non-GAAP measures for operating results as non-GAAP results. These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP. Ionis reports these non-GAAP results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows. Further, the presentation of Ionis' non-GAAP results is consistent with how Ionis' management internally evaluates the performance of its operations.
 
8
IONIS PHARMACEUTICALS, INC.
Condensed Consolidated Balance Sheets
(In Millions)

   
September 30,
    
December 31,
  
   
2021
    
2020
  
         
(as revised*)
  
   
(unaudited)
  
Assets:
            
Cash, cash equivalents and short-term investments
  
$
1,987
    
$
1,892
  
Contracts receivable
    
9
      
76
  
Other current assets
    
160
      
162
  
Property, plant and equipment, net
    
180
      
181
  
Other assets
    
79
      
79
  
Total assets
  
$
2,415
    
$
2,390
  
                 
Liabilities and stockholders’ equity:
                
Other current liabilities
  
$
120
    
$
183
  
Current portion of 1% convertible senior notes, net
    
62
      
309
  
Current portion of deferred contract revenue
    
98
      
108
  
0% convertible senior notes, net
    
618
      
-
  
0.125% convertible senior notes, net
    
542
      
540
  
Long-term obligations, less current portion
    
81
      
83
  
Long-term deferred contract revenue
    
363
      
424
  
Total stockholders’ equity
    
531
      
743
  
Total liabilities and stockholders’ equity
  
$
2,415
    
$
2,390
  

*The Company revised its 2020 amounts to reflect the simplified convertible instruments guidance the Company adopted retrospectively on January 1, 2021.
 
#   #   #


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Document and Entity Information
Nov. 03, 2021
Cover [Abstract]  
Document Type 8-K
Amendment Flag false
Document Period End Date Nov. 03, 2021
Entity Registrant Name IONIS PHARMACEUTICALS, INC.
Entity Incorporation, State or Country Code DE
Entity File Number 000-19125
Entity Tax Identification Number 33-0336973
Entity Address, Address Line One 2855 Gazelle Court
Entity Address, City or Town Carlsbad
Entity Address, State or Province CA
Entity Address, Postal Zip Code 92010
City Area Code 760
Local Phone Number 931-9200
Written Communications false
Soliciting Material false
Pre-commencement Tender Offer false
Pre-commencement Issuer Tender Offer false
Entity Emerging Growth Company false
Entity Central Index Key 0000874015
Title of 12(b) Security Common Stock, $.001 Par Value
Trading Symbol “IONS”
Security Exchange Name NASDAQ
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