<SEC-DOCUMENT>0001140361-20-030055-index.html : 20201231
<SEC-HEADER>0001140361-20-030055.hdr.sgml : 20201231
<ACCEPTANCE-DATETIME>20201231162056
ACCESSION NUMBER:		0001140361-20-030055
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		7
FILED AS OF DATE:		20201231
DATE AS OF CHANGE:		20201231
EFFECTIVENESS DATE:		20201231

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-251855
		FILM NUMBER:		201429055

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8
<SEQUENCE>1
<FILENAME>brhc10018560_s8.htm
<DESCRIPTION>S-8
<TEXT>
Document 1 - file: brhc10018560_s8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>brhc10018560_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: brhc10018560_ex5-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>brhc10018560_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: brhc10018560_ex23-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>4
<FILENAME>brhc10018560_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
Document 4 - file: brhc10018560_ex99-1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>5
<FILENAME>brhc10018560_ex99-2.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
Document 5 - file: brhc10018560_ex99-2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>6
<FILENAME>brhc10018560_ex99-3.htm
<DESCRIPTION>EXHIBIT 99.3
<TEXT>
Document 6 - file: brhc10018560_ex99-3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.4
<SEQUENCE>7
<FILENAME>brhc10018560_ex99-4.htm
<DESCRIPTION>EXHIBIT 99.4
<TEXT>
Document 7 - file: brhc10018560_ex99-4.htm

</DOCUMENT>
</SEC-DOCUMENT>