<SEC-DOCUMENT>0001140361-20-009606-index.html : 20200424
<SEC-HEADER>0001140361-20-009606.hdr.sgml : 20200424
<ACCEPTANCE-DATETIME>20200424060215
ACCESSION NUMBER:		0001140361-20-009606
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		20
CONFORMED PERIOD OF REPORT:	20200604
FILED AS OF DATE:		20200424
DATE AS OF CHANGE:		20200424
EFFECTIVENESS DATE:		20200424

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		20812392

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
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Document 1 - file: nc10007589x2_def14a.htm

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Document 2 - file: nc10007589x2_barchart01.jpg

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Document 3 - file: nc10007589x2_barchart02.jpg

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Document 4 - file: nc10007589x2_diagram01.jpg

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Document 5 - file: nc10007589x2_diagram02.jpg

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Document 6 - file: nc10007589x2_diagram03.jpg

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Document 7 - file: nc10007589x2_pickup01.jpg

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Document 8 - file: nc10007589x2_pickup02.jpg

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Document 9 - file: nc10007589x2_pickup03.jpg

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Document 10 - file: nc10007589x2_pickup04.jpg

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Document 11 - file: nc10007589x2_pickup05.jpg

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Document 12 - file: nc10007589x2_pickup06.jpg

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Document 13 - file: nc10007589x2_pickup07.jpg

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Document 14 - file: nc10007589x2_pickup08.jpg

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<FILENAME>nc10007589x2_pickup09.jpg
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Document 15 - file: nc10007589x2_pickup09.jpg

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Document 16 - file: nc10007589x2_pickup10.jpg

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Document 17 - file: nc10007589x2_pickup11.jpg

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Document 18 - file: nc10007589x2_pickup12.jpg

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Document 19 - file: nc10007589x2_proxycards01.jpg

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Document 20 - file: nc10007589x2_proxycards02.jpg

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