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Segment Information (Tables)
6 Months Ended
Jun. 30, 2019
Segment Information [Abstract]  
Segment Information

The following tables show our segment revenue and income (loss) from operations for the three and six months ended June 30, 2019 and 2018 (in thousands), respectively.


Three Months Ended June 30, 2019
 
Ionis Core
   
Akcea Therapeutics
   
Elimination of
Intercompany Activity
   
Total
 
Revenue:
                       
Commercial revenue:
                       
SPINRAZA royalties
 
$
70,502
   
$
   
$
   
$
70,502
 
TEGSEDI product sales, net
   
     
9,865
     
     
9,865
 
Licensing and other royalty revenue
   
4,896
     
6,036
     
(3,000
)
   
7,932
 
Total commercial revenue
   
75,398
     
15,901
     
(3,000
)
   
88,299
 
R&D revenue under collaborative agreements
   
64,791
     
10,723
     
     
75,514
 
Total segment revenue
 
$
140,189
   
$
26,624
   
$
(3,000
)
 
$
163,813
 
Total operating expenses
 
$
121,774
   
$
65,328
   
$
(4,462
)
 
$
182,640
 
Income (loss) from operations
 
$
18,415
   
$
(38,704
)
 
$
1,462
   
$
(18,827
)

Three Months Ended June 30, 2018
 
Ionis Core
   
Akcea Therapeutics
   
Elimination of
Intercompany Activity
   
Total
 
Revenue:
                       
Commercial revenue:
                       
SPINRAZA royalties
 
$
56,653
   
$
   
$
   
$
56,653
 
Licensing and other royalty revenue
   
545
     
     
     
545
 
Total commercial revenue
   
57,198
     
     
     
57,198
 
R&D revenue under collaborative agreements
   
42,228
     
18,321
     
     
60,549
 
Total segment revenue
 
$
99,426
   
$
18,321
   
$
   
$
117,747
 
Total operating expenses
 
$
85,875
   
$
81,744
   
$
409
   
$
168,028
 
Income (loss) from operations
 
$
13,551
   
$
(63,423
)
 
$
(409
)
 
$
(50,281
)

Six Months Ended June 30, 2019
 
Ionis Core
   
Akcea Therapeutics
   
Elimination of
Intercompany Activity
   
Total
 
Revenue:
                       
Commercial revenue:
                       
SPINRAZA royalties
 
$
130,212
   
$
   
$
   
$
130,212
 
TEGSEDI product sales, net
   
     
16,619
     
     
16,619
 
Licensing and other royalty revenue
   
6,519
     
6,036
     
(3,000
)
   
9,555
 
Total commercial revenue
   
136,731
     
22,655
     
(3,000
)
   
156,386
 
R&D revenue under collaborative agreements
   
225,347
     
167,785
     
(88,492
)
   
304,640
 
Total segment revenue
 
$
362,078
   
$
190,440
   
$
(91,492
)
 
$
461,026
 
Total operating expenses
 
$
236,290
   
$
202,938
   
$
(80,908
)
 
$
358,320
 
Income (loss) from operations
 
$
125,788
   
$
(12,498
)
 
$
(10,584
)
 
$
102,706
 

Six Months Ended June 30, 2018
 
Ionis Core
   
Akcea Therapeutics
   
Elimination of
Intercompany Activity
   
Total
 
Revenue:
                       
Commercial revenue:
                       
SPINRAZA royalties
 
$
97,734
   
$
   
$
   
$
97,734
 
Licensing and other royalty revenue
   
1,487
     
     
     
1,487
 
Total commercial revenue
   
99,221
     
     
     
99,221
 
R&D revenue under collaborative agreements
   
132,744
     
35,429
     
(5,229
)
   
162,944
 
Total segment revenue
 
$
231,965
   
$
35,429
   
$
(5,229
)
 
$
262,165
 
Total operating expenses
 
$
191,419
   
$
129,179
   
$
(4,850
)
 
$
315,748
 
Income (loss) from operations
 
$
40,546
   
$
(93,750
)
 
$
(379
)
 
$
(53,583
)


The following table shows our total assets by segment at June 30, 2019 and December 31, 2018 (in thousands), respectively.


Total Assets
 
Ionis Core
   
Akcea Therapeutics
   
Elimination of
Intercompany Activity
   
Total
 
June 30, 2019
 
$
3,173,752
   
$
434,120
   
$
(730,107
)
 
$
2,877,765
 
December 31, 2018
 
$
2,975,491
   
$
365,261
   
$
(672,968
)
 
$
2,667,784