CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 272,523	$ 278,820
Short-term investments	1,989,508	1,805,252
Contracts receivable	31,615	12,759
Inventories	18,505	8,582
Other current assets	102,071	102,473
Total current assets	2,414,222	2,207,886
Property, plant and equipment, net	135,349	132,160
Patents, net	26,056	24,032
Long-term deferred tax assets	276,360	290,796
Deposits and other assets	25,778	12,910
Total assets	2,877,765	2,667,784
Current liabilities:
Accounts payable	15,628	28,660
Accrued compensation	20,049	29,268
Accrued liabilities	49,681	47,503
Income taxes payable	4,035	858
Current portion of long-term obligations	14,432	13,749
Current portion of deferred contract revenue	137,388	160,256
Total current liabilities	241,213	280,294
Long-term deferred contract revenue	516,584	567,359
1 percent convertible senior notes	586,797	568,215
Long-term obligations, less current portion	16,091	4,914
Long-term mortgage debt	59,878	59,842
Total liabilities	1,420,563	1,480,624
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 140,393,074 and 137,928,828 shares issued and outstanding at June 30, 2019 (unaudited) and December 31, 2018, respectively	140	138
Additional paid-in capital	2,177,222	2,047,250
Accumulated other comprehensive loss	(24,252)	(32,016)
Accumulated deficit	(883,726)	(967,293)
Total Ionis stockholders' equity	1,269,384	1,048,079
Noncontrolling interest in Akcea Therapeutics, Inc.	187,818	139,081
Total stockholders' equity	1,457,202	1,187,160
Total liabilities and stockholders' equity	$ 2,877,765	$ 2,667,784