<SEC-DOCUMENT>0001140361-19-007625-index.html : 20190426
<SEC-HEADER>0001140361-19-007625.hdr.sgml : 20190426
<ACCEPTANCE-DATETIME>20190426061252
ACCESSION NUMBER:		0001140361-19-007625
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		21
CONFORMED PERIOD OF REPORT:	20190606
FILED AS OF DATE:		20190426
DATE AS OF CHANGE:		20190426
EFFECTIVENESS DATE:		20190426

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		19769274

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
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Document 1 - file: nc10001158x1_def14a.htm

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Document 2 - file: nc10001158x1_barchart1.jpg

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Document 3 - file: nc10001158x1_barchart2.jpg

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Document 4 - file: nc10001158x1_barchart3.jpg

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Document 5 - file: nc10001158x1_graphic1.jpg

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Document 6 - file: nc10001158x1_pc01.jpg

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Document 7 - file: nc10001158x1_pc02.jpg

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<TEXT>
Document 8 - file: nc10001158x1_pickup1.jpg

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Document 9 - file: nc10001158x1_pickup2.jpg

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Document 10 - file: nc10001158x1_pickup3.jpg

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Document 11 - file: nc10001158x1_pickup4.jpg

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<FILENAME>nc10001158x1_pickup5.jpg
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Document 12 - file: nc10001158x1_pickup5.jpg

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Document 13 - file: nc10001158x1_pickup6.jpg

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Document 14 - file: nc10001158x1_pickup7.jpg

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Document 15 - file: nc10001158x1_pickup8.jpg

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Document 16 - file: nc10001158x1_pickup9.jpg

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Document 17 - file: nc10001158x1_pickup10.jpg

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Document 18 - file: nc10001158x1_pickup11.jpg

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Document 19 - file: nc10001158x1_pickup12.jpg

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Document 20 - file: nc10001158x1_pickup13.jpg

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<FILENAME>nc10001158x1_pyramid.jpg
<TEXT>
Document 21 - file: nc10001158x1_pyramid.jpg

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