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Collaborative Arrangements and Licensing Agreements, Intellectual Property Sale and Licensing Agreements (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
May 31, 2016
Jan. 31, 2009
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Revenue earned     $ 160,349 $ 110,927 $ 38,470 $ 36,874 $ 51,571 $ 49,121 $ 120,428 $ 62,583 $ 346,620 $ 283,703 $ 214,161
Payments for sublicense revenue and post licensing milestone payments                     4,421 4,056 3,586
Abbott Molecular Inc. [Member]                          
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Sales price of interest owned in subsidiary   $ 215,000                      
Revenue earned                     0 $ 0 $ 0
Abbott Molecular Inc. [Member] | Minimum [Member]                          
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Cumulative net sales threshold used to calculate earn out payments                     140,000    
Annual net sales threshold used to calculate earn out payments                     $ 50,000    
Percentage of cumulative net sales used to calculate earn out payments, over $140 million and up to $2.1 billion                     2.50%    
Percentage of cumulative net sales used to calculate earn out payments, over $2.1 billion                     1.50%    
Abbott Molecular Inc. [Member] | Maximum [Member]                          
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Cumulative net sales threshold used to calculate earn out payments                     $ 2,100,000    
Percentage of cumulative net sales used to calculate earn out payments, over $140 million and up to $2.1 billion                     5.00%    
Percentage of cumulative net sales used to calculate earn out payments, over $2.1 billion                     3.00%    
Kastle Therapeutics [Member]                          
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Revenue earned                     $ 15,100    
Maximum amount of payments receivable     95,000               95,000    
Upfront payment received $ 15,000                        
Next potential payment     10,000               10,000    
Maximum amount of payments receivable for commercialization milestones     $ 70,000               $ 70,000    
Royalty percentage received on sales of drug                     3.00%    
Ownership interest percentage     10.00%               10.00%    
Royalty percentage on sales of Kynamro to be paid to Sanofi Genzyme                     3.00%    
Percentage of non-royalty cash payments received from Kastle to be paid to Sanofi Genzyme                     3.00%    
Cold Spring Harbor Laboratory [Member]                          
Collaborative Arrangement and Licensing Agreement [Abstract]                          
Maximum amount of payments payable for sublicense revenue and post licensing milestone payments     $ 11,300               $ 11,300    
Payments for sublicense revenue and post licensing milestone payments                     $ 3,400