Collaborative Arrangements and Licensing Agreements, Satellite Company Collaborations - Atlantic Pharmaceuticals Limited (Details) - USD ($)	1 Months Ended	3 Months Ended								12 Months Ended
	Mar. 31, 2007	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2016	Dec. 31, 2015		Dec. 31, 2014		Dec. 31, 2013	Dec. 31, 2010
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned		$ 160,349,000	$ 110,927,000	$ 38,470,000	$ 36,874,000	$ 51,571,000	$ 49,121,000	$ 120,428,000	$ 62,583,000	$ 346,620,000	$ 283,703,000		$ 214,161,000
Atlantic Pharmaceuticals Limited [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Ownership interest percentage		9.00%				11.00%				9.00%	11.00%
Atlantic Pharmaceuticals Limited [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Upfront fee in the form of equity securities	$ 2,000,000
Maximum amount of payments receivable for regulatory milestones		$ 1,400,000								$ 1,400,000
Next prospective milestone		$ 600,000								600,000
Revenue earned										$ 0	$ 0	[1]	$ 0	[1]	$ 0	$ 0

[1] Revenue from this relationship was negligible for the year.