Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 194,372	$ 218,493
R&D credits	193,845	153,601
Deferred revenue	54,203	45,110
Stock-based compensation	48,209	31,093
Other	26,228	19,655
Total deferred tax assets	516,857	467,952
Deferred Tax Liabilities [Abstract]
Convertible debt	(62,669)	(55,928)
Unrealized gain in other comprehensive income	0	(5,288)
Intangible and capital assets	(2,030)	(2,643)
Net deferred tax asset	452,158	404,093
Valuation allowance	(452,158)	(404,093)
Net deferreds	0	0
Excess tax benefits from shared-based compensation awards	1,861	$ 396	$ 1,463
Unrealized excess tax benefits associated with share-based compensation	$ 82,500