Long-Term Obligations and Commitments, Research and Development Facility Lease Obligation (Details) $ in Thousands	1 Months Ended	12 Months Ended
	Mar. 31, 2010 USD ($)	Dec. 31, 2016 USD ($) Option	Dec. 31, 2015 USD ($)
Research and Development Facility Lease Obligation [Abstract]
Net book value		$ 92,845	$ 90,233
Accumulated depreciation		$ 80,075	72,706
Primary Research and Development Facility [Member]
Research and Development Facility Lease Obligation [Abstract]
Number of options to extend lease | Option		4
Term of lease extension		5 years
Net book value		$ 60,000	62,200
Accumulated depreciation		12,100	$ 9,900
Purchase price of land	$ 10,100
Annual Future Rent Payments [Abstract]
2017		6,550
2018		6,943
2019		6,943
2020		7,359
2021		7,359
Thereafter		83,846
Total minimum payments		$ 119,000