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Fair Value Measurements (Tables)
3 Months Ended
Mar. 31, 2014
Fair Value Measurements [Abstract]  
Schedule of assets measured at fair value on a recurring basis

We measure the following major security types at fair value on a recurring basis. We break down the inputs used to measure fair value for these assets at March 31, 2014 and December 31, 2013 as follows (in thousands):

 
 
At March 31,
2014
  
Quoted Prices in
Active Markets
(Level 1)
  
Significant Other
Observable
Inputs
(Level 2)
  
Significant
Unobservable
Inputs
(Level 3)
 
Cash equivalents (1)
 
$
149,945
  
$
141,013
  
$
8,932
  
$
 
Corporate debt securities (2)
  
344,930
   
   
344,930
   
 
Debt securities issued by U.S. government agencies (2)
  
67,598
   
   
67,598
   
 
Debt securities issued by the U.S. Treasury (2)
  
15,298
   
15,298
   
   
 
Debt securities issued by states of the United States and political subdivisions of the states (2)
  
41,689
   
   
41,689
   
 
Investment in Regulus Therapeutics Inc.
  
63,586
   
63,586
   
   
 
Equity securities (3)
  
2,903
   
985
   
   
1,918
 
Total
 
$
685,949
  
$
220,882
  
$
463,149
  
$
1,918
 

 
 
 
At December 31,
2013
  
Quoted Prices in
Active Markets
(Level 1)
  
Significant Other
Observable
Inputs
(Level 2)
  
Significant
Unobservable
Inputs
(Level 3)
 
Cash equivalents (1)
 
$
146,357
  
$
133,233
  
$
13,124
  
$
 
Corporate debt securities (2)
  
394,773
   
   
394,773
   
 
Debt securities issued by U.S. government agencies (2)
  
64,432
   
   
64,432
   
 
Debt securities issued by the U.S. Treasury (2)
  
15,328
   
15,328
   
   
 
Debt securities issued by states of the United States and political subdivisions of the states (2)
  
22,255
   
   
22,255
   
 
Investment in Regulus Therapeutics Inc.
  
52,096
   
52,096
   
   
 
Equity securities (3)
  
1,276
   
1,276
   
   
 
Total
 
$
696,517
  
$
201,933
  
$
494,584
  
$
 
 

(1)Included in cash and cash equivalents on our condensed consolidated balance sheet.

(2)Included in short-term investments on our condensed consolidated balance sheet.

(3)Included in other current assets on our condensed consolidated balance sheet.
Summary of investments measured at fair value on a recurring basis using significant unobservable inputs (Level 3)
The following is a summary of our investments measured at fair value on a recurring basis using significant unobservable inputs (Level 3) for the three months ended March 31, 2014 and 2013 (in thousands):

 
 
Three Months Ended
March 31,
 
 
 
2014
  
2013
 
 
 
  
 
Beginning balance of Level 3 investments
 
$
  
$
34,350
 
Total gains and losses:
        
Included in gain on investments
  
   
(1,163
)
Included in accumulated other comprehensive income (loss)
  
1,918
   
11,716
 
Cost basis of shares sold
  
   
(40
)
Ending balance of Level 3 investments
 
$
1,918
  
$
44,863