-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, LivSDUhJt/flpxwULnlQv3Bm6z9ODXDUA2JrLelsaLa/ah2O4a/0xy8Mm+Qr5agW Uas4akO4pgLs8uUZZ7wbXg== 0001140361-05-001318.txt : 20050214 0001140361-05-001318.hdr.sgml : 20050214 20050214164026 ACCESSION NUMBER: 0001140361-05-001318 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20050214 DATE AS OF CHANGE: 20050214 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-41771 FILM NUMBER: 05611284 BUSINESS ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2292 FARADAY AVE CITY: CARLSBAD STATE: CA ZIP: 92008 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: MAZAMA CAPITAL MANAGEMENT INC CENTRAL INDEX KEY: 0001078779 IRS NUMBER: 911858217 STATE OF INCORPORATION: OR FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: ONE SW COLUMBIA STREET 2: STE 1860 CITY: PORTLAND STATE: OR ZIP: 97258 BUSINESS PHONE: 5032218725 MAIL ADDRESS: STREET 1: ONE SW COLUMBIA STREET 2: STE 1860 CITY: PORTLAND STATE: OR ZIP: 97258 FORMER COMPANY: FORMER CONFORMED NAME: MAZAMA CAPITAL MANAGEMENT LLC DATE OF NAME CHANGE: 19990209 SC 13G/A 1 doc1.htm Schedule 13G
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. 02 )*


Isis Pharmaceuticals
(Name of Issuer)


Class A Common
(Title of Class of Securities)


464330109
(CUSIP Number)


December 31, 2004
(Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 
[ X ]  Rule 13d-1(b)
[ ]  Rule 13d-1(c)
[ ]  Rule 13d-1(d)
 

* The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 




SCHEDULE 13G
CUSIP No. 464330109

  1. Names of Reporting Persons.
MAZAMA CAPITAL MANAGEMENT, INC.
I.R.S. Identification Nos. of above persons (entities only).
93-1290809

  2. Check the Appropriate Box if a Member of a Group (See Instructions)
(a)  [    ]       (b)  [    ]

  3. SEC USE ONLY

  4. Citizenship or Place of Organization
OREGON

Number of
Shares
Beneficially
Owned by
Each Reporting
Person With:
5. Sole Voting Power
2,466,150 See Item 4

6. Shared Voting Power
0

7. Sole Dispositive Power
4,372,702 See Item 4

8. Shared Dispositive Power
0

  9. Aggregate Amount Beneficially Owned by Each Reporting Person
4,372,702

  10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  [    ]

  11. Percent of Class Represented by Amount in Row (9)
7.63%

  12. Type of Reporting Person
IA


         


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Item 1.

 

(a)

Name of Issuer

         Isis Pharmaceuticals

 

(b)

Address of Issuer's Principal Executive Offices

2292 Faraday Avenue
Carlsbad, CA 92008


Item 2.

 

(a)

Name of Person Filing

Mazama Capital Management, Inc.

 

(b)

Address of Principal Business Office or, if none, Residence

One S.W. Columbia, Suite 1500, Portland, Oregon 97258

 

(c)

Citizenship

State of Oregon

 

(d)

Title of Class of Securities

Class A Common

 

(e)

CUSIP Number

464330109


Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

 

(a)

[    ]

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

 

(b)

[    ]

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

 

(c)

[    ]

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

 

(d)

[    ]

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C 80a-8).

 

(e)

[ X ]

An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

 

(f)

[    ]

An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

 

(g)

[    ]

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

 

(h)

[    ]

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

 

(i)

[    ]

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

 

(j)

[    ]

Group, in accordance with §240.13d-1(b)(1)(ii)(J).


Item 4.

Ownership.

 

(a)

Amount beneficially owned:

         4,372,702

 

(b)

Percent of class:

         7.63%

 

(c)

Number of shares as to which the person has:

 

 

(i)

Sole power to vote or to direct the vote

         2,466,150

 

 

(ii)

Shared power to vote or to direct the vote

         0

 

 

(iii)

Sole power to dispose or to direct the disposition of

         4,372,702

 

 

(iv)

Shared power to dispose or to direct the disposition of

         0


Item 5.

Ownership of Five Percent or Less of a Class

          If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [    ].


Instruction: Dissolution of a group requires a response to this item.

         N/A


Item 6.

Ownership of More than Five Percent on Behalf of Another Person

                  N/A


Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company

                  N/A


Item 8.

Identification and Classification of Members of the Group

                  N/A


Item 9.

Notice of Dissolution of Group

                  N/A


Item 10.

Certification

                   By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.


SIGNATURE

        After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 
Date:   February 10, 2005
  Mazama Capital Management, Inc.

  By: /s/ Brian P. Alfrey
      Brian P. Alfrey
  Title:    Executive Vice President and Chief Operating Officer 
 
 


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