<SEC-DOCUMENT>0001104659-22-016034-index.html : 20220209
<SEC-HEADER>0001104659-22-016034.hdr.sgml : 20220209
<ACCEPTANCE-DATETIME>20220209122725
ACCESSION NUMBER:		0001104659-22-016034
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220209
DATE AS OF CHANGE:		20220209

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-41771
		FILM NUMBER:		22605350

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARK Investment Management LLC
		CENTRAL INDEX KEY:			0001697748
		IRS NUMBER:				464309299
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		200 CENTRAL AVENUE
		CITY:			ST. PETERSBURG
		STATE:			FL
		ZIP:			33701
		BUSINESS PHONE:		212-426-7040

	MAIL ADDRESS:	
		STREET 1:		200 CENTRAL AVENUE
		CITY:			ST. PETERSBURG
		STATE:			FL
		ZIP:			33701
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>tm225659d6_sc13g.htm
<DESCRIPTION>SC 13G
<TEXT>
Document 1 - file: tm225659d6_sc13g.htm

</DOCUMENT>
</SEC-DOCUMENT>