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Organization and Significant Accounting Policies (Details 6) (USD $)
In Millions, unless otherwise specified
12 Months Ended 3 Months Ended
Dec. 31, 2013
item
Dec. 31, 2012
item
Dec. 31, 2013
Maximum
Dec. 31, 2012
Collaborations and Licensing Agreements
Regulus Therapeutics Inc.
Maximum
Equity method of accounting        
Ownership percentage     20.00% 20.00%
Consolidation of variable interest entities        
Number of variable interest entities in which the entity is not primary beneficiary 5 6    
Carrying value of investments in variable interest entities $ 53.4