CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011
Net cash used in operating activities	$ (34,159)	$ (89,188)
Investing activities:
Purchases of short-term investments	(172,581)	(284,379)
Proceeds from the sale of short-term investments	189,397	371,872
Purchases of property, plant and equipment	(1,033)	(8,934)
Acquisition of licenses and other assets, net	(2,779)	(2,544)
Purchases of strategic investments	(40)	(359)
Net cash provided by investing activities	12,964	75,656
Financing activities:
Proceeds from issuance of equity	7,789	1,554
Proceeds from issuance of 2 3/4 percent convertible senior notes, net of issuance costs	194,689
Principal and premium payment on redemption of the 2 5/8 percent convertible subordinated notes	(163,718)
Proceeds from equipment financing arrangement	9,100	1,625
Principal payments on debt and capital lease obligations	(7,579)	(4,436)
Net cash provided by (used in) financing activities	40,281	(1,257)
Net increase (decrease) in cash and cash equivalents	19,086	(14,789)
Cash and cash equivalents at beginning of period	65,477	70,052
Cash and cash equivalents at end of period	84,563	55,263
Supplemental disclosures of cash flow information:
Interest paid	5,584	4,647
Income taxes paid		2
Supplemental disclosures of non-cash investing and financing activities:
Amounts accrued for capital and patent expenditures	839	1,378
Capitalized costs and financing liability associated with leased facility		$ 58,748