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Organization and Significant Accounting Policies (Details 5) (USD $)
In Millions, unless otherwise specified
12 Months Ended
Dec. 31, 2011
entity
segment
Dec. 31, 2010
entity
segment
Dec. 31, 2009
entity
Consolidation of variable interest entities      
Number of variable interest entities in which the entity is not primary beneficiary 6 8  
Number of variable interest entities in which the entity is the primary beneficiary     1
Segment information      
Number of reportable segments prior to 2011   2  
Regulus Therapeutics Inc.
     
Equity method of accounting      
Principal plus accrued interest guaranteed on Regulus convertible notes 5.5