CONDENSED CONSOLIDATED BALANCE SHEETS (USD $) In Thousands	Jun. 30, 2011	Dec. 31, 2010
Current assets:
Cash and cash equivalents	$ 85,022	$ 70,052
Short-term investments	310,162	402,301
Contracts receivable	5,674	1,242
Inventories	2,249	2,484
Other current assets	7,613	7,058
Total current assets	410,720	483,137
Property, plant and equipment, net	88,010	35,703
Licenses, net	11,129	12,288
Patents, net	16,444	15,821
Deposits and other assets	3,269	3,528
Total assets	529,572	550,477
Current liabilities:
Accounts payable	3,071	6,523
Accrued compensation	4,406	6,831
Accrued liabilities	10,873	12,389
Current portion of long-term obligations	4,911	5,645
Current portion of deferred contract revenue	68,719	74,502
Total current liabilities	91,980	105,890
Long-term deferred contract revenue	21,356	50,413
2 5/8% convertible subordinated notes	137,073	132,895
Long-term obligations, less current portion	5,465	5,720
Long-term financing liability for leased facility	58,722	10,147
Investment in Regulus Therapeutics Inc.	2,759	870
Total liabilities	317,355	305,935
Stockholders' equity:
Common stock, $0.001 par value; 200,000,000 shares authorized, 99,618,525 and 99,393,780 shares issued and outstanding at June 30, 2011 and December 31, 2010, respectively	100	99
Additional paid-in capital	1,006,288	1,000,181
Accumulated other comprehensive income	399	949
Accumulated deficit	(794,570)	(756,687)
Total stockholders' equity	212,217	244,542
Total liabilities and stockholders' equity	$ 529,572	$ 550,477