<SEC-DOCUMENT>0001088875-20-000003-index.html : 20200116
<SEC-HEADER>0001088875-20-000003.hdr.sgml : 20200116
<ACCEPTANCE-DATETIME>20200116084026
ACCESSION NUMBER:		0001088875-20-000003
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20200116
DATE AS OF CHANGE:		20200116

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-41771
		FILM NUMBER:		20529501

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BAILLIE GIFFORD & CO
		CENTRAL INDEX KEY:			0001088875
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		CALTON SQUARE
		STREET 2:		1 GREENSIDE ROW
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH13AN
		BUSINESS PHONE:		00441312752000

	MAIL ADDRESS:	
		STREET 1:		CALTON SQUARE
		STREET 2:		1 GREENSIDE ROW
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH13AN
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>ionispharmaceuticals31122019.txt
<TEXT>
Document 1 - file: ionispharmaceuticals31122019.txt

</DOCUMENT>
</SEC-DOCUMENT>