X0609 4 2026-07-07 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0002102721 Kordasiewicz Holly B. false 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP, Chief Development Officer 1 Common Stock 2026-07-07 4 S 0 362 84.3 D 22096 D Shares sold pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on March 13, 2026 By: Patrick R. O’Neil, attorney-in-fact For: Holly B. Kordasiewicz 2026-07-09