CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2026	Mar. 31, 2025
Operating activities:
Net loss	$ (92,528)	$ (146,938)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	3,301	2,228
Amortization of right-of-use operating lease assets	3,485	2,587
Amortization of other assets	661	582
Amortization of discount on investments, net	(6,190)	(7,108)
Amortization of debt issuance costs	2,349	1,642
Non-cash royalty revenue related to sale of royalties	(11,689)	(12,891)
Non-cash interest related to sale of future royalties	17,184	18,670
Stock-based compensation expense	43,275	29,718
Loss (gain) on investments, net	(22,583)	1,849
Non-cash losses related to other assets	40	61
Changes in operating assets and liabilities:
Escrow deposit for maturity of 0 percent convertible senior notes due April 2026	(632,511)
Contracts receivable	(7,625)	52,481
Inventories	338	1,010
Other current and long-term assets	(7,390)	(12,366)
Accounts payable	(3,095)	(25,968)
Income taxes	161	92
Accrued compensation	(80,187)	(43,039)
Accrued liabilities and other liabilities	21,003	333
Deferred contract revenue	(20,818)	(13,718)
Net cash used in operating activities	(792,819)	(150,775)
Investing activities:
Purchases of short-term investments	(192,755)	(311,068)
Proceeds from sale of short-term investments	752,824	494,755
Purchases of property, plant and equipment	(21,763)	(12,577)
Acquisition of licenses and other assets, net	(1,486)	(651)
Net cash provided by investing activities	536,820	170,459
Financing activities:
Proceeds from issuance of common stock through equity plans, net	57,302	2,241
Principal payments on mortgage debt	(44)	(42)
Net cash provided by financing activities	57,258	2,199
Effects of exchange rates on cash	(138)	232
Net increase (decrease) in cash and cash equivalents	(198,879)	22,115
Cash and cash equivalents at beginning of period	372,260	242,077
Cash and cash equivalents at end of period	173,381	264,192
Supplemental disclosures of cash flow information:
Interest paid	90	92
Income tax refunds received, net	(8)	(400)
Supplemental disclosures of non-cash investing and financing activities:
Amounts accrued for capital and patent expenditures	$ 1,043	$ 460