CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2026	Dec. 31, 2025
Current assets:
Cash and cash equivalents	$ 173,381	$ 372,260
Short-term investments	1,745,732	2,305,176
Escrow deposit for maturity of 0 percent convertible senior notes due April 2026	632,511	0
Contracts receivable	73,684	66,059
Inventories	5,557	10,048
Other current assets	306,080	237,092
Total current assets	2,936,945	2,990,635
Property, plant and equipment, net	142,401	123,048
Right-of-use assets	235,064	238,549
Deposits and other assets	135,559	171,604
Total assets	3,449,969	3,523,836
Current liabilities:
Accounts payable	26,030	28,082
Accrued compensation	36,049	116,236
Accrued liabilities	126,549	106,089
Income taxes payable	2,874	2,713
0 percent convertible senior notes due April 2026	432,500	431,948
Current portion of deferred contract revenue	69,199	73,761
Other current liabilities	23,390	22,738
Total current liabilities	716,591	781,567
Long-term deferred contract revenue	75,745	92,001
Liability related to sale of future royalties, net	557,765	551,353
Long-term lease liabilities	259,215	262,383
Long-term obligations	28,274	28,118
Total liabilities	2,958,555	3,034,747
Stockholders’ equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 165,902,064 and 163,304,875 shares issued and outstanding at March 31, 2026 and December 31, 2025, respectively	166	163
Additional paid-in capital	3,245,994	3,145,402
Accumulated other comprehensive loss	(31,023)	(25,281)
Accumulated deficit	(2,723,723)	(2,631,195)
Total stockholders' equity	491,414	489,089
Total liabilities and stockholders’ equity	3,449,969	3,523,836
0% Notes due 2030 [Member]
Current liabilities:
Convertible senior notes, net	752,425	751,495
1.75% Notes due 2028 [Member]
Current liabilities:
Convertible senior notes, net	$ 568,540	$ 567,830