X0508 4 2026-02-27 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0001073387 BENNETT C FRANK 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP, Chief Scientific Officer 0 Common Stock 2026-02-27 4 J 0 261 48.8665 A 100554 D Reporting shares purchased under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on February 27, 2026. These shares may not be sold until August 27, 2026. By: Patrick R. O'Neil, attorney-in-fact For: C. Frank Bennett 2026-03-03