X0206 3 2025-12-21 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0002102721 Kordasiewicz Holly B. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 EVP, Chief Development Officer Common Stock 7740 D Non-Qualified Stock Option (right to buy) 32.6 2023-01-03 2032-01-02 Common Stock 12000 D Non-Qualified Stock Option (right to buy) 34.69 2026-01-02 2035-01-01 Common Stock 10000 D Non-Qualified Stock Option (right to buy) 37.58 2024-01-03 2033-01-02 Common Stock 11500 D Non-Qualified Stock Option (right to buy) 52.87 2025-01-02 2034-01-01 Common Stock 19800 D Non-Qualified Stock Option (right to buy) 56.78 2022-01-04 2028-01-03 Common Stock 19895 D Non-Qualified Stock Option (right to buy) 60.89 2021-01-02 2027-01-01 Common Stock 28951 D Restricted Stock Unit 0.0 2026-01-15 Common Stock 31949 D Each restricted stock unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Grants to reporting person of restricted stock units under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan on January 15, 2022, January 15, 2023, January 15, 2024, and January 15, 2025. The restricted stock units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. By: Patrick R. O'Neil, attorney-in-fact For: Holly Kordasiewicz 2026-01-05