CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Operating activities:
Net loss	$ (151,993)	$ (349,548)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	6,749	7,374
Amortization of right-of-use operating lease assets	6,803	7,472
Amortization of other assets	1,801	1,877
Amortization of discount on investments, net	(18,063)	(28,283)
Amortization of debt issuance costs	4,940	5,016
Non-cash royalty revenue related to sale of royalties	(38,478)	(30,422)
Non-cash interest related to sale of future royalties	54,964	54,330
Stock-based compensation expense	90,554	94,052
Loss (gain) on investments, net	(9,437)	320
Non-cash losses related to other assets	(3,643)	1,009
Changes in operating assets and liabilities:
Contracts receivable	67,580	79,850
Inventories	(14,600)	(27)
Other current and long-term assets	(123,489)	(8,155)
Accounts payable	(29,116)	(19,215)
Income taxes	67	(2,110)
Accrued compensation	(12,595)	(27,169)
Accrued liabilities and other current liabilities	87,683	(28,661)
Deferred contract revenue	(50,601)	(142,518)
Net cash used in operating activities	(130,874)	(384,808)
Investing activities:
Purchases of short-term investments	(1,126,595)	(1,519,227)
Proceeds from sale of short-term investments	1,302,751	1,339,284
Purchases of property, plant and equipment	(30,152)	(19,783)
Acquisition of licenses and other assets, net	(4,275)	(2,514)
Net cash provided by (used in) investing activities	141,729	(202,240)
Financing activities:
Proceeds from issuance of common stock through equity plans, net	84,787	33,207
Proceeds from issuance of common stock in public offering, net	0	489,093
Principal payments on mortgage debt	(123)	(126)
Net cash provided by financing activities	84,664	522,174
Effects of exchange rates on cash	745	213
Net increase (decrease) in cash and cash equivalents	96,264	(64,661)
Cash and cash equivalents at beginning of period	242,077	399,266
Cash and cash equivalents at end of period	338,341	334,605
Supplemental disclosures of cash flow information:
Interest paid	5,399	5,714
Income taxes paid (refunds received), net	(661)	2,072
Supplemental disclosures of non-cash investing and financing activities:
Right-of-use assets obtained in exchange for lease obligations	86,939	0
Amounts accrued for capital and patent expenditures	$ 478	$ 2,240