CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Operating activities:
Net loss	$ (23,387)	$ (209,068)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation	4,494	5,013
Amortization of right-of-use operating lease assets	5,177	4,957
Amortization of other assets	1,180	1,260
Amortization of discount on investments, net	(12,978)	(19,143)
Amortization of debt issuance costs	3,288	3,338
Non-cash royalty revenue related to sale of royalties	(24,894)	(16,236)
Non-cash interest related to sale of future royalties	37,165	35,949
Stock-based compensation expense	59,408	62,068
Loss on investments, net	20,471	1,201
Non-cash losses related to other assets	297	389
Changes in operating assets and liabilities:
Contracts receivable	39,608	70,519
Inventories	(12,465)	(298)
Other current and long-term assets	(22,536)	(9,381)
Accounts payable	(20,309)	(17,064)
Income taxes	47	(1,867)
Accrued compensation	(23,050)	(32,709)
Accrued liabilities and other current liabilities	3,535	(39,201)
Deferred contract revenue	(34,488)	(109,545)
Net cash provided by (used in) operating activities	563	(269,818)
Investing activities:
Purchases of short-term investments	(802,657)	(803,867)
Proceeds from sale of short-term investments	880,545	968,413
Purchases of property, plant and equipment	(24,882)	(10,727)
Acquisition of licenses and other assets, net	(2,615)	(15,264)
Net cash provided by investing activities	50,391	138,555
Financing activities:
Proceeds from issuance of common stock through equity plans, net	3,528	26,205
Principal payments on mortgage debt	(82)	(78)
Net cash provided by financing activities	3,446	26,127
Effects of exchange rates on cash	827	(137)
Net increase (decrease) in cash and cash equivalents	55,227	(105,273)
Cash and cash equivalents at beginning of period	242,077	399,266
Cash and cash equivalents at end of period	297,304	293,993
Supplemental disclosures of cash flow information:
Interest paid	5,214	5,569
Income taxes paid (refunds received), net	(383)	1,992
Supplemental disclosures of non-cash investing and financing activities:
Right-of-use assets obtained in exchange for lease obligations	7,253	0
Amounts accrued for capital and patent expenditures	$ 145	$ 1,453