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Insider Trading Arrangements
 3 Months Ended
Jun. 30, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
During the quarter ended June 30, 2025, our directors and officers (as defined in Rule 16a-1(f) under the Exchange Act), or Section 16 officers and directors, adopted or terminated contracts, instructions or written plans for the purchase or sale of our securities as noted in the table below.
*       Contract, instruction or written plan intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act.
**    "Non-Rule 10b5-1 trading arrangement" as defined in item 408(c) of Regulation S-K under the Exchange Act.
     Trading Arrangement   
 Action Date Rule 10b5-1* Non-Rule 10b5-1** Total Shares To Be Sold Expiration Date
Frank Bennett, EVP, Chief Scientific OfficerTermination May 6, 2025 X    104,079  Upon the execution of all instructions included in the plan
Joseph Baroldi, EVP, Chief Business OfficerAdoption May 2, 2025 X    87,874  The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Patrick O' Neil, EVP, Chief Legal Officer and General CounselAdoption May 2, 2025 X    237,477  The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Eugene Schneider, EVP, Chief Clinical Development and Operations OfficerAdoption May 2, 2025 X    38,756  The earlier to occur of (i) August 3, 2026, and (ii) Upon the execution of all instructions provided in the plan
Richard Geary, EVP, Chief Development OfficerAdoption May 6, 2025 X    220,870  The earlier to occur of (i) July 31, 2026, and (ii) Upon the execution of all instructions provided in the plan
B. Lynne Parshall, Board MemberAdoption May 6, 2025 X    41,993  The earlier to occur of (i) May 31, 2026, and (ii) Upon the execution of all instructions provided in the plan
Frank Bennett, EVP, Chief Scientific OfficerAdoption May 13, 2025 X    67,800  The earlier to occur of (i) August 17, 2026, and (ii) Upon the execution of all instructions provided in the plan
Termination [Member] | Frank Bennett [Member]  
Trading Arrangements, by Individual  
Name Frank Bennett
Title Chief Scientific Officer
Rule 10b5-1 Arrangement Terminated true
Non-Rule 10b5-1 Arrangement Terminated true
Termination Date May 6, 2025
Expiration Date May 6, 2025
Aggregate Available 104,079
Adoption [Member] | Frank Bennett [Member]  
Trading Arrangements, by Individual  
Name Frank Bennett
Title Chief Scientific Officer
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 13, 2025
Expiration Date August 17, 2026
Arrangement Duration 462 days
Aggregate Available 67,800
Adoption [Member] | Joseph Baroldi [Member]  
Trading Arrangements, by Individual  
Name Joseph Baroldi
Title Chief Business Officer
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 2, 2025
Expiration Date August 3, 2026
Arrangement Duration 459 days
Aggregate Available 87,874
Adoption [Member] | Patrick O' Neil [Member]  
Trading Arrangements, by Individual  
Name Patrick O' Neil
Title Chief Legal Officer and General Counsel
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 2, 2025
Expiration Date August 3, 2026
Arrangement Duration 459 days
Aggregate Available 237,477
Adoption [Member] | Eugene Schneider [Member]  
Trading Arrangements, by Individual  
Name Eugene Schneider
Title Chief Clinical Development and Operations Officer
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 2, 2025
Expiration Date August 3, 2026
Arrangement Duration 459 days
Aggregate Available 38,756
Adoption [Member] | Richard Geary [Member]  
Trading Arrangements, by Individual  
Name Richard Geary
Title Chief Development Officer
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 6, 2025
Expiration Date July 31, 2026
Arrangement Duration 452 days
Aggregate Available 220,870
Adoption [Member] | B. Lynne Parshall [Member]  
Trading Arrangements, by Individual  
Name B. Lynne Parshall
Title Board Member
Rule 10b5-1 Arrangement Adopted true
Non-Rule 10b5-1 Arrangement Adopted false
Adoption Date May 6, 2025
Expiration Date May 31, 2026
Arrangement Duration 391 days
Aggregate Available 41,993