Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 95,851	$ 77,964
Tax credits	310,703	239,962
Deferred revenue	54,063	71,683
Stock-based compensation	82,660	77,468
Intangible and capital assets	93,541	104,380
Convertible debt	9,310	16,849
Capitalized research and development expenses	323,560	238,738
Long-term lease liabilities	41,481	43,718
Sale of future royalties	148,918	144,608
Other	14,024	10,343
Total deferred tax assets	1,174,111	1,025,713
Deferred Tax Liabilities [Abstract]
Fixed assets	(5,719)	(4,166)
Right-of-use assets	(36,788)	(42,007)
Other	(1,896)	(1,910)
Net deferred tax asset	1,129,708	977,630
Valuation allowance	(1,129,708)	(977,630)
Total net deferred tax assets and liabilities	0	$ 0
Increase in valuation allowance	$ 152,000