Income Taxes, Reconciliation of Statutory to Effective Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Reconciliation Between Effective and Statutory Tax Rate [Abstract]
Pre-tax loss	$ (460,068)	$ (333,965)	$ (257,985)
Statutory rate	(96,614)	(70,133)	(54,177)
State income tax net of federal benefit	(11,889)	(22,597)	(13,622)
Foreign	15	(22)	(49)
Net change in valuation allowance	152,590	175,388	104,951
Tax credits	(53,497)	(67,131)	(39,729)
Tax rate change	10,815	1,023	(3,091)
Non-deductible compensation	1,895	3,814	3,023
Other non-deductible items	188	327	57
Foreign-derived intangible income benefit	(21,071)	(7,493)	0
Stock-based compensation	10,732	19,546	14,030
Other	665	(401)	344
Total income tax expense (benefit)	$ (6,171)	$ 32,321	$ 11,737
Reconciliation Between Effective and Statutory Tax Rate Percentage [Abstract]
Statutory rate	21.00%	21.00%	21.00%
State income tax net of federal benefit	2.60%	6.80%	5.30%
Foreign	0.00%	0.00%	0.00%
Net change in valuation allowance	(33.20%)	(52.50%)	(40.70%)
Tax credits	11.60%	20.10%	15.40%
Tax rate change	(2.40%)	(0.30%)	1.20%
Non-deductible compensation	(0.40%)	(1.10%)	(1.20%)
Other non-deductible items	0.00%	(0.10%)	0.00%
Foreign-derived intangible income benefit	4.60%	2.20%	0.00%
Stock-based compensation	(2.30%)	(5.90%)	(5.40%)
Other	(0.20%)	0.10%	(0.10%)
Effective rate	1.30%	(9.70%)	(4.50%)