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Cumulative payments received since inception of the collaboration agreement included in the transaction price for the performance obligation.

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No definition available.

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Cumulative amount of payments received under the collaboration agreement as of the end of the reporting period.

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No definition available.

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The maximum amount of development milestone payments to be received over the term of the collaboration.

+ References

No definition available.

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- Definition

The maximum amount of license fees to be received over the term of the collaboration.

+ References

No definition available.

+ Details

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- Definition

The maximum amount of payments the Company is eligible to receive over the term of the collaboration.

+ References

No definition available.

+ Details

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- Definition

The maximum amount of regulatory milestone payments to be received over the term of the collaboration.

+ References

No definition available.

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- Definition

The maximum amount of sales milestone payments to be received over the term of the collaboration.

+ References

No definition available.

+ Details

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The next payment to be achieved under the collaboration agreement.

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No definition available.

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The percentage of royalty payments paid on annual sales of medicine.

+ References

No definition available.

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The potential premium received if common stock was purchased in the future under a Stock Purchase Agreement (SPA) in conjunction with the collaboration agreement.

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No definition available.

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The total amount of the premium received over the trading price of common stock at the time of purchase.

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No definition available.

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The number of separate performance obligations under the collaboration agreement.

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No definition available.

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The amount of consideration the Company earned or is eligible to earn under the collaboration agreement, including any variable consideration.

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No definition available.

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Royalty percentage received on the net sales of a medicine by a collaboration partner under the collaboration agreement.

+ References

No definition available.

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The amount of upfront payments received during the period under the collaboration agreement.

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No definition available.

+ Details

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- Definition

For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaborative Arrangements and Licensing Agreements, Novartis (Details) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2023 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2017 USD ($)	Aug. 31, 2023 PerformanceObligation	Mar. 31, 2017 PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 705,138	$ 787,647	$ 587,367
Pelacarsen API [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Percentage of royalty payments paid to Royalty Pharma on annual sales of medicine		25.00%
Novartis [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 37,762	30,194	$ 237
Deferred contract revenue	$ 30,000	$ 4,200	$ 30,000
Novartis [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage		5.00%	4.00%
Novartis [Member] \| Maximum [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage				1.00%
Pelacarsen [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable over term of collaboration		$ 900,000
Upfront payment received					$ 75,000
Maximum amount of license fees over term of collaboration		150,000
Maximum amount of development milestone payments over term of collaboration		25,000
Maximum amount of regulatory milestone payments over term of collaboration		290,000
Maximum amount of sales milestone payments over term of collaboration		360,000
Cumulative payments received		275,000
Next payment to be achieved		50,000
Number of separate performance obligations \| PerformanceObligation							4
Transaction price					108,400
Premium received on shares issued					28,400
Potential premium received if common stock was purchased in the future					$ 5,000
Cumulative payments included in transaction price for performance obligation		$ 104,000
Pelacarsen [Member] \| Pelacarsen API [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine		20.00%
Lp(a)-Driven Cardiovascular Disease [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable over term of collaboration		$ 730,000
Upfront payment received	$ 60,000
Maximum amount of development milestone payments over term of collaboration		155,000
Maximum amount of regulatory milestone payments over term of collaboration		105,000
Maximum amount of sales milestone payments over term of collaboration		410,000
Cumulative payments received		65,000
Next payment to be achieved		10,000
Number of separate performance obligations \| PerformanceObligation						1
Transaction price		$ 65,000
Lp(a)-Driven Cardiovascular Disease [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine		10.00%
Lp(a)-Driven Cardiovascular Disease [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine		20.00%