CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2024	Sep. 30, 2024	Sep. 30, 2023	Sep. 30, 2024	Sep. 30, 2023	Dec. 31, 2023
Operating activities:
Net loss		$ (140,480)	$ (147,410)	$ (349,548)	$ (357,023)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation				7,374	7,748
Amortization of right-of-use operating lease assets				7,472	7,234
Amortization of other assets				1,877	1,904
Amortization of discount on investments, net				(28,283)	(20,396)
Amortization of debt issuance costs				5,016	4,666
Non-cash royalty revenue related to sale of royalties				(30,422)	(27,814)
Non-cash interest related to sale of future royalties				54,330	50,541
Stock-based compensation expense				94,052	79,473
Loss on investments				320	1,429
Gain on early retirement of debt				0	(13,389)
Non-cash losses related to disposal of property, plant and equipment				114	14,646
Non-cash losses related to other assets				895	849
Changes in operating assets and liabilities:
Contracts receivable				79,850	(116,814)
Inventories				(27)	(3,601)
Other current and long-term assets				(8,155)	(18,325)
Income taxes				(2,110)	24,821
Accounts payable				(19,215)	(12,462)
Accrued compensation				(27,169)	(15,397)
Accrued liabilities and other current liabilities				(28,661)	(24,219)
Deferred contract revenue				(142,518)	75,751
Net cash used in operating activities				(384,808)	(340,378)
Investing activities:
Purchases of short-term investments				(1,519,227)	(1,353,100)
Proceeds from sale of short-term investments				1,339,284	1,193,724
Purchases of property, plant and equipment				(19,783)	(24,624)
Acquisition of licenses and other assets, net				(2,514)	(3,414)
Net cash used in investing activities				(202,240)	(187,414)
Financing activities:
Proceeds from issuance of common stock through equity plans, net				33,207	8,680
Proceeds from issuance of common stock in public offering, net	$ 489,100			489,093	0
Proceeds from issuance of 1.75 percent convertible senior notes				0	575,000
1.75 percent convertible senior notes issuance costs				0	(14,175)
Repurchase of $504.4 million principal amount of 0.125 percent convertible senior notes				0	(487,943)
Proceeds from sale of future royalties				0	500,000
Payments of transaction costs related to sale of future royalties				0	(10,434)
Proceeds from real estate transaction				0	32,352
Principal payments on mortgage debt				(126)	(122)
Net cash provided by financing activities				522,174	603,358
Effects of exchange rates on cash				213	22
Net increase (decrease) in cash and cash equivalents				(64,661)	75,588
Cash and cash equivalents at beginning of period				399,266	276,472	$ 276,472
Cash and cash equivalents at end of period	$ 334,605	$ 334,605	$ 352,060	334,605	352,060	$ 399,266
Supplemental disclosures of cash flow information:
Interest paid				5,714	952
Income taxes paid				2,072	714
Supplemental disclosures of non-cash investing and financing activities:
Amounts accrued for capital and patent expenditures				$ 2,240	$ 341