CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2024	Jun. 30, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023
Operating activities:
Net loss	$ (66,265)	$ (85,290)	$ (209,068)	$ (209,613)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation			5,013	5,225
Amortization of right-of-use operating lease assets			4,957	4,826
Amortization of other assets			1,260	1,244
Amortization of discount on investments, net			(19,143)	(12,481)
Amortization of debt issuance costs			3,338	2,966
Non-cash royalty revenue related to sale of royalties			(16,236)	(12,562)
Non-cash interest related to sale of future royalties			35,949	32,915
Stock-based compensation expense			62,068	53,510
Loss (gain) on investments			1,201	(301)
Gain on early retirement of debt			0	(11,292)
Non-cash losses related to other assets			389	775
Changes in operating assets and liabilities:
Contracts receivable			70,519	(2,254)
Inventories			(298)	(3,505)
Other current and long-term assets			(9,381)	(19,696)
Income taxes			(1,867)	18,483
Accounts payable			(17,064)	5,517
Accrued compensation			(32,709)	(19,856)
Accrued liabilities and other current liabilities			(39,201)	(37,562)
Deferred contract revenue			(109,545)	(27,695)
Net cash used in operating activities			(269,818)	(231,356)
Investing activities:
Purchases of short-term investments			(803,867)	(932,362)
Proceeds from sale of short-term investments			968,413	701,034
Purchases of property, plant and equipment			(10,727)	(22,483)
Acquisition of licenses and other assets, net			(15,264)	(2,314)
Net cash provided by (used in) investing activities			138,555	(256,125)
Financing activities:
Proceeds from equity, net			26,205	4,950
Proceeds from issuance of 1.75 percent convertible senior notes			0	575,000
1.75 percent convertible senior notes issuance costs			0	(13,658)
Repurchase of $434.1 million principal amount of 0.125 percent convertible senior notes			0	(420,158)
Proceeds from sale of future royalties			0	500,000
Payments of transaction costs related to sale of future royalties			0	(10,434)
Principal payments on mortgage debt			(78)	(75)
Net cash provided by financing activities			26,127	635,625
Effects of exchange rates on cash			(137)	174
Net increase (decrease) in cash and cash equivalents			(105,273)	148,318
Cash and cash equivalents at beginning of period			399,266	276,472	$ 276,472
Cash and cash equivalents at end of period	$ 293,993	$ 424,790	293,993	424,790	$ 399,266
Supplemental disclosures of cash flow information:
Interest paid			5,569	529
Income taxes paid			1,992	510
Supplemental disclosures of non-cash investing and financing activities:
Amounts accrued for capital and patent expenditures			$ 1,453	$ 251