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Document and Entity Information - shares
6 Months Ended
Jun. 30, 2024
Jul. 26, 2024
Cover [Abstract]    
Document Type 10-Q  
Amendment Flag false  
Document Quarterly Report true  
Document Period End Date Jun. 30, 2024  
Current Fiscal Year End Date --12-31  
Document Fiscal Year Focus 2024  
Document Fiscal Period Focus Q2  
Document Transition Report false  
Entity File Number 000-19125  
Entity Registrant Name Ionis Pharmaceuticals, Inc.  
Entity Central Index Key 0000874015  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 33-0336973  
Entity Address, Address Line One 2855 Gazelle Court  
Entity Address, City or Town Carlsbad  
Entity Address, State or Province CA  
Entity Address, Postal Zip Code 92010  
City Area Code 760  
Local Phone Number 931-9200  
Title of 12(b) Security Common Stock, $.001 Par Value  
Trading Symbol IONS  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Large Accelerated Filer  
Entity Small Business false  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   146,211,091