Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 77,964	$ 87,802
Tax credits	239,962	277,436
Deferred revenue	71,683	85,700
Stock-based compensation	77,468	86,983
Intangible and capital assets	104,380	104,649
Convertible debt	16,849	34,384
Capitalized research and development expenses	238,738	119,635
Long-term lease liabilities	43,718	45,612
Sale of future royalties	144,608	0
Other	10,343	15,813
Total deferred tax assets	1,025,713	858,014
Deferred Tax Liabilities [Abstract]
Fixed assets	(4,166)	(4,475)
Right-of-use assets	(42,007)	(44,504)
Other	(1,910)	(313)
Net deferred tax asset	977,630	808,722
Valuation allowance	(977,630)	(808,722)
Total net deferred tax assets and liabilities	0	$ 0
Increase in valuation allowance	$ 169,000