CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating activities:
Net loss	$ (366,286)	$ (269,722)	$ (28,597)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Depreciation	10,292	14,328	15,487
Amortization of right-of-use operating lease assets	9,647	5,362	1,721
Amortization of other assets	2,559	2,415	2,352
Amortization of premium (discount) on investments, net	(28,885)	7,389	17,776
Amortization of debt issuance costs	6,330	5,373	4,958
Non-cash royalty revenue related to sale of royalties	(44,628)	0	0
Non-cash interest related to sale of future royalties	68,238	0	0
Stock-based compensation expense	105,809	100,264	120,678
Loss (gain) on early retirement of debt	(13,389)	0	8,627
Non-cash losses related to disposal of property, plant and equipment	16,649	531	0
Loss (gain) on sale of real estate assets	161	(150,135)	0
Loss (gain) on investments	1,589	224	(1,092)
Non-cash losses related to other assets	1,661	2,030	2,707
Changes in operating assets and liabilities:
Contracts receivable	(72,059)	36,358	14,308
Inventories	(6,392)	2,773	(2,841)
Other current and long-term assets	(29,840)	(24,682)	(877)
Accounts payable	8,119	1,094	(6,000)
Income taxes	(4,098)	6,213	(280)
Accrued compensation	18,549	10,368	(26,918)
Accrued liabilities and other current liabilities	(5,506)	46,695	(8,381)
Deferred contract revenue	13,967	(71,248)	(82,829)
Net cash provided by (used in) operating activities	(307,513)	(274,370)	30,799
Investing activities:
Purchases of short-term investments	(1,770,814)	(1,485,772)	(1,124,193)
Proceeds from sale of short-term investments	1,584,676	989,152	1,344,185
Purchases of property, plant and equipment	(23,805)	(15,721)	(11,955)
Proceeds from sale of real estate assets	22	254,083	0
Acquisition of licenses and other assets, net	(4,206)	(4,378)	(5,946)
Purchases of strategic investments	0	0	(7,185)
Net cash provided by (used in) investing activities	(214,127)	(262,636)	194,906
Financing activities:
Proceeds from equity, net	49,442	6,373	11,565
Payments of tax withholdings related to vesting of employee stock awards and exercise of employee stock options	0	(10,953)	(16,725)
Proceeds from sale of future royalties	500,000	0	0
Payments of transaction costs related to sale of future royalties	(10,434)	(29)	0
Proceeds from real estate transaction	32,352	0	0
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity	0	0	(61,967)
Proceeds from issuance of warrants	0	0	89,752
Purchase of note hedges	0	0	(136,620)
Principal payments on debt	(160)	(50,686)	0
Net cash provided by (used in) financing activities	644,082	(55,295)	245,933
Effects of exchange rates on cash	352	(418)	(111)
Net increase (decrease) in cash and cash equivalents	122,794	(592,719)	471,527
Cash and cash equivalents at beginning of year	276,472	869,191	397,664
Cash and cash equivalents at end of year	399,266	276,472	869,191
Supplemental disclosures of cash flow information:
Interest paid	6,512	2,898	4,778
Income taxes paid	48,334	5,010	38
Supplemental disclosures of non-cash investing and financing activities:
Right-of-use assets obtained in exchange for lease liabilities	0	168,931	6,641
Amounts accrued for capital and patent expenditures	172	4,767	705
1.75 Percent Convertible Senior Notes [Member]
Financing activities:
Proceeds from issuance of convertible senior notes	575,000	0	0
Convertible senior notes issuance costs	(14,175)	0	0
0.125 Percent Convertible Senior Notes [Member]
Financing activities:
Repurchase of convertible senior notes	(487,943)	0	0
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity	(504,400)
0 Percent Convertible Senior Notes [Member]
Financing activities:
Proceeds from issuance of convertible senior notes	0	0	632,500
Convertible senior notes issuance costs	0	0	(15,609)
Proceeds from issuance of warrants			89,800
Purchase of note hedges			(136,700)
1 Percent Convertible Senior Notes [Member]
Financing activities:
Repurchase of convertible senior notes	$ 0	$ 0	(256,963)
Repayment of remaining principal amount of 1 percent convertible senior notes at maturity			$ (309,900)