No definition available.

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- Definition

Cumulative amount of payments received under the collaboration agreement as of the end of the reporting period.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

The maximum amount of payments the Company is eligible to receive over the term of the collaboration.

+ References

No definition available.

+ Details

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- Definition

The maximum amount of regulatory milestone payments to be received over the term of the collaboration.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
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- Definition

The maximum amount of sales milestone payments to be received over the term of the collaboration.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
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- Definition

The next payment to be achieved under the collaboration agreement.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant

- Definition

The number of separate performance obligations under the collaboration agreement.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:integerItemType
Balance Type:	na
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- Definition

The amount of consideration the Company earned or is eligible to earn under the collaboration agreement, including any variable consideration.

+ References

No definition available.

+ Details

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Royalty percentage received on the net sales of a medicine by a collaboration partner under the collaboration agreement.

+ References

No definition available.

+ Details

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Balance Type:	na
Period Type:	duration

- Definition

The amount of upfront payments received during the period under the collaboration agreement.

+ References

No definition available.

+ Details

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Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- Definition

For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

+ References

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Period Type:	duration

- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

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Balance Type:	credit
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- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaborative Arrangements and Licensing Agreements, Otsuka (Details) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2023 USD ($) PerformanceObligation	Dec. 31, 2023 USD ($) PerformanceObligation	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 787,647	$ 587,367	$ 810,456
Otsuka [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable over term of collaboration	$ 185,000	185,000
Upfront payment received	65,000
Maximum amount of regulatory milestone payments over term of collaboration	50,000	50,000
Maximum amount of sales milestone payments over term of collaboration	70,000	70,000
Cumulative payments received	65,000	65,000
Next payment to be achieved	$ 15,000	$ 15,000
Number of separate performance obligations \| PerformanceObligation	2	2
Transaction price	$ 65,000	$ 65,000
Revenue		56,480
Deferred revenue	8,500	$ 8,500
Otsuka [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage		7.00%
Otsuka [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine		20.00%
Otsuka [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine		30.00%
Otsuka [Member] \| License of Donidalorsen [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Transaction price	56,000	$ 56,000
Otsuka [Member] \| R&D Services for Donidalorsen [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Transaction price	$ 9,000	$ 9,000