Collaborative Arrangements and Licensing Agreements, Sobi (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2023	Sep. 30, 2022	Sep. 30, 2023	Sep. 30, 2022
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue	$ 144,207	$ 159,767	$ 463,142	$ 435,478
Sobi [Member] | Revenue [Member] | Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage	1.00%	1.00%	2.00%	1.00%
Sobi [Member] | TEGSEDI Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue	$ 794	$ 1,008	$ 2,189	$ 3,443