CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 352,060	$ 276,472
Short-term investments	1,883,522	1,710,397
Contracts receivable	142,359	25,538
Inventories	25,634	22,033
Other current assets	181,075	168,254
Total current assets	2,584,650	2,202,694
Property, plant and equipment, net	70,928	74,294
Right-of-use assets	174,310	181,544
Deposits and other assets	104,083	75,344
Total assets	2,933,971	2,533,876
Current liabilities:
Accounts payable	5,615	17,921
Accrued compensation	33,781	49,178
Accrued liabilities	118,968	140,101
Income taxes payable	31,070	6,249
Current portion of deferred contract revenue	204,824	90,577
Other current liabilities	9,952	7,535
Total current liabilities	404,210	311,561
Long-term deferred contract revenue	249,272	287,768
Liability related to sale of future royalties, net	512,700	0
Long-term lease liabilities	173,038	178,941
Long-term obligations	48,801	15,973
Total liabilities	2,618,511	1,960,989
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 143,393,493 and 142,057,736 shares issued and outstanding at September 30, 2023 (unaudited) and December 31, 2022, respectively	143	142
Additional paid-in capital	2,148,002	2,059,850
Accumulated other comprehensive loss	(46,037)	(57,480)
Accumulated deficit	(1,786,648)	(1,429,625)
Total stockholders' equity	315,460	572,887
Total liabilities and stockholders' equity	2,933,971	2,533,876
1.75 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	561,609	0
0 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	624,594	622,242
0.125 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	$ 44,287	$ 544,504