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No definition available.

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The number of collaboration agreements with the collaboration partner.

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaborative Arrangements and Licensing Agreements, AstraZeneca (Details) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023 USD ($) Agreement	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($) Agreement	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue	$ 188,411	$ 133,791	$ 318,935	$ 275,710
AstraZeneca [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of collaboration agreements \| Agreement	2		2
Revenue	$ 59,501	$ 17,768	$ 83,926	$ 37,611
Deferred revenue	$ 0		$ 0		$ 0
AstraZeneca [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage	32.00%	13.00%	26.00%	14.00%
AstraZeneca [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	$ 610,000		$ 610,000
Eplontersen Collaboration [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of collaboration agreements \| Agreement	1		1
Revenue	$ 20,000
Eplontersen Collaboration [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Next payment to be achieved	$ 50,000		$ 50,000
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of collaboration agreements \| Agreement	1		1
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Next payment to be achieved	$ 30,000		$ 30,000
Cardiovascular, Renal and Metabolic Diseases Collaboration [Member] \| ION839 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue	$ 20,000