CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 424,790	$ 276,472
Short-term investments	1,960,598	1,710,397
Contracts receivable	27,956	25,538
Inventories	25,538	22,033
Other current assets	177,872	168,254
Total current assets	2,616,754	2,202,694
Property, plant and equipment, net	91,634	74,294
Right-of-use assets	176,718	181,544
Deposits and other assets	86,025	75,344
Total assets	2,971,131	2,533,876
Current liabilities:
Accounts payable	24,021	17,921
Accrued compensation	29,322	49,178
Accrued liabilities	104,745	140,101
Income taxes payable	24,732	6,249
Current portion of deferred contract revenue	96,252	90,577
Other current liabilities	8,903	7,535
Total current liabilities	287,975	311,561
Long-term deferred contract revenue	254,398	287,768
Liability related to sale of future royalties, net	510,174	0
Long-term lease liabilities	175,020	178,941
Long-term obligations	16,436	15,973
Total liabilities	2,542,830	1,960,989
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 143,167,414 and 142,057,736 shares issued and outstanding at June 30, 2023 (unaudited) and December 31, 2022, respectivel	143	142
Additional paid-in capital	2,118,309	2,059,850
Accumulated other comprehensive loss	(50,913)	(57,480)
Accumulated deficit	(1,639,238)	(1,429,625)
Total stockholders' equity	428,301	572,887
Total liabilities and stockholders' equity	2,971,131	2,533,876
1.75 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	560,937	0
0 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	623,809	622,242
0.125 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	$ 114,081	$ 544,504