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Liability Related to Sale of Future Royalties (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Jan. 31, 2023
Mar. 31, 2023
Mar. 31, 2022
Royalty Revenue Monetization [Abstract]      
Transaction costs   $ 10,434 $ 0
Proceeds from sale of future royalties   500,000 0
Interest expense related to sale of future royalties   15,363 $ 0
Net liability related to sale of future royalties   505,081  
Royalty Purchase Agreement [Member]      
Royalty Revenue Monetization [Abstract]      
Upfront payment received $ 500,000    
Maximum amount of payments receivable for additional milestones   $ 625,000  
Effective interest rate   13.50%  
Transaction costs   $ 10,400  
Proceeds from sale of future royalties   500,000  
Interest expense related to sale of future royalties   15,363  
Liability related to sale of future royalties as of   515,363  
Net issuance costs related to sale of future royalties   (10,282)  
Net liability related to sale of future royalties   505,081  
Royalty Purchase Agreement [Member] | SPINRAZA [Member]      
Royalty Revenue Monetization [Abstract]      
Maximum amount of annual sales on which royalty payments are paid   $ 1,500,000  
Royalty Purchase Agreement [Member] | SPINRAZA [Member] | Minimum [Member]      
Royalty Revenue Monetization [Abstract]      
Percentage of royalty payments paid on annual sales of medicine   25.00%  
Maximum royalty payments made before royalty interest reverts back   $ 475,000  
Royalty Purchase Agreement [Member] | SPINRAZA [Member] | Maximum [Member]      
Royalty Revenue Monetization [Abstract]      
Percentage of royalty payments paid on annual sales of medicine   45.00%  
Maximum royalty payments made before royalty interest reverts back   $ 550,000  
Royalty Purchase Agreement [Member] | Pelacarsen [Member]      
Royalty Revenue Monetization [Abstract]      
Percentage of royalty payments paid on annual sales of medicine   25.00%