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Collaborative Arrangements and Licensing Agreements, GSK (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Dec. 31, 2022
Collaborative Arrangement and Licensing Agreement [Abstract]      
Revenue $ 130,524 $ 141,919  
R&D Revenue [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Revenue 62,756 $ 69,634  
GSK [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Next payment to be achieved 15,000    
Deferred revenue $ 0   $ 0
GSK [Member] | Revenue [Member] | Strategic Partner [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Concentration percentage 11.00% 0.00%  
GSK [Member] | Minimum [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Cumulative payments received $ 105,000    
GSK [Member] | R&D Revenue [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Revenue 15,000 $ 0  
GSK [Member] | Bepirovirsen [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Revenue $ 15,000